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Literature summary extracted from

  • Meyer, H.; Panz, M.; Zmojdzian, M.; Jagla, K.; Paululat, A.
    Neprilysin 4, a novel endopeptidase from Drosophila melanogaster, displays distinct substrate specificities and exceptional solubility states (2009), J. Exp. Biol., 212, 3673-3683.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.11 expressed as a GST-fusion protein in Escherichia coli Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.11 phosphoramidon
-
Drosophila melanogaster
3.4.24.11 thiorphan
-
Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.11 membrane isoform A is expressed as a membrane bound protein Drosophila melanogaster 16020
-
3.4.24.11 soluble isoform B is expressed as a soluble protein Drosophila melanogaster
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.11 113000
-
isoform B, SDS-PAGE using purified NEP4 antiserum Drosophila melanogaster
3.4.24.11 120000
-
isoform A, SDS-PAGE using purified NEP4 antiserum Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.11 Drosophila melanogaster
-
-
-
3.4.24.11 Drosophila melanogaster Q9I7I4
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.11 embryo expression is demonstrated during embryogenesis in pericardial cells, muscle founder cells, glia cells and male gonads. At least one isoform of NEP4 is found in every developmental stage Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.11 angiotensin I + H2O 51.6% degradation Drosophila melanogaster ?
-
?
3.4.24.11 bradykinin + H2O 27.8% degradation Drosophila melanogaster ?
-
?
3.4.24.11 Substance P + H2O 85.8% degradation Drosophila melanogaster ?
-
?
3.4.24.11 tachykinin + H2O 27.8% degradation Drosophila melanogaster ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.11 NEP4A
-
Drosophila melanogaster
3.4.24.11 NEP4B
-
Drosophila melanogaster
3.4.24.11 neprilysin 4 two isoforms exist due to different splice-variants: larger isoform A is expressed as a membrane bound protein and isoform B lacking the N-terminal cytosolic and transmembrane region is expressed as a soluble protein Drosophila melanogaster

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.11 35
-
assay at Drosophila melanogaster

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.11 7
-
-
Drosophila melanogaster