EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.24.11 | expressed as a GST-fusion protein in Escherichia coli | Drosophila melanogaster |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.11 | phosphoramidon | - |
Drosophila melanogaster | |
3.4.24.11 | thiorphan | - |
Drosophila melanogaster |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.24.11 | membrane | isoform A is expressed as a membrane bound protein | Drosophila melanogaster | 16020 | - |
3.4.24.11 | soluble | isoform B is expressed as a soluble protein | Drosophila melanogaster | - |
- |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.24.11 | 113000 | - |
isoform B, SDS-PAGE using purified NEP4 antiserum | Drosophila melanogaster |
3.4.24.11 | 120000 | - |
isoform A, SDS-PAGE using purified NEP4 antiserum | Drosophila melanogaster |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.11 | Drosophila melanogaster | - |
- |
- |
3.4.24.11 | Drosophila melanogaster | Q9I7I4 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.11 | embryo | expression is demonstrated during embryogenesis in pericardial cells, muscle founder cells, glia cells and male gonads. At least one isoform of NEP4 is found in every developmental stage | Drosophila melanogaster | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.11 | angiotensin I + H2O | 51.6% degradation | Drosophila melanogaster | ? | - |
? | |
3.4.24.11 | bradykinin + H2O | 27.8% degradation | Drosophila melanogaster | ? | - |
? | |
3.4.24.11 | Substance P + H2O | 85.8% degradation | Drosophila melanogaster | ? | - |
? | |
3.4.24.11 | tachykinin + H2O | 27.8% degradation | Drosophila melanogaster | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.11 | NEP4A | - |
Drosophila melanogaster |
3.4.24.11 | NEP4B | - |
Drosophila melanogaster |
3.4.24.11 | neprilysin 4 | two isoforms exist due to different splice-variants: larger isoform A is expressed as a membrane bound protein and isoform B lacking the N-terminal cytosolic and transmembrane region is expressed as a soluble protein | Drosophila melanogaster |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.24.11 | 35 | - |
assay at | Drosophila melanogaster |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.24.11 | 7 | - |
- |
Drosophila melanogaster |