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Literature summary extracted from

  • Ojeda, D.; Jimenez-Ferrer, E.; Zamilpa, A.; Herrera-Arellano, A.; Tortoriello, J.; Alvarez, L.
    Inhibition of angiotensin convertin enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa (2010), J. Ethnopharmacol., 127, 7-10.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 cyanidin-3-O-sambubioside an anthocyanin isolated from Hibiscus sabdariffa calyces, competitive ACE inhibition reducing blood pressure in humans, IC50 is 0.0684 mg/ml Oryctolagus cuniculus
3.4.15.1 delphinidin-3-O-sambubioside an anthocyanin isolated from Hibiscus sabdariffa calyces, competitive ACE inhibition reducing blood pressure in humans, IC50 is 0.0845 mg/ml Oryctolagus cuniculus
3.4.15.1 lisinopril
-
 Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.15.1 additional information
-
 additional information kinetics Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.15.1 NaCl activates Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 commercial preparation
-
 Oryctolagus cuniculus
-
3.4.15.1 lung
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 N-[3-(2-furyl)acryloyl]-L-phenylalanyl-glycyl-glycine + H2O
-
 Oryctolagus cuniculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 ACE
-
 Oryctolagus cuniculus
3.4.15.1 angiotensin converting enzyme
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.15.1 37
-
 assay at Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.15.1 8.3
-
 assay at Oryctolagus cuniculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.15.1 0.00028
-
 lisinopril pH 8.3, 37°C Oryctolagus cuniculus
3.4.15.1 0.0319
-
 delphinidin-3-O-sambubioside pH 8.3, 37°C Oryctolagus cuniculus
3.4.15.1 0.0569
-
 cyanidin-3-O-sambubioside pH 8.3, 37°C Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.15.1 0.0018
-
 pH 8.3, 37°C Oryctolagus cuniculus lisinopril
3.4.15.1 0.1178
-
 pH 8.3, 37°C Oryctolagus cuniculus cyanidin-3-O-sambubioside
3.4.15.1 0.1416
-
 pH 8.3, 37°C Oryctolagus cuniculus delphinidin-3-O-sambubioside