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Literature summary extracted from

  • Ye, D.; Ma, T.Y.
    Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alpha-induced regulation of myosin light chain kinase gene activity (2008), J. Cell. Mol. Med., 12, 1331-1346.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 Caco-2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain
-
 Homo sapiens ADP + myosin light chain phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 MLCK
-
 Homo sapiens
2.7.11.18 myosin light chain kinase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.11.18 Homo sapiens 10 ng/ml tumour necrosis factor-alpha causes a significant increase of myosin light chain kinase gene activity, tumour necrosis factor-alpha causes an increase in nuclear factor-kappaB to the nuclear factor-kappaB1 binding motif which presumably leads to the activation of MLCK promoter up