Literature summary extracted from

Khuon, S.; Liang, L.; Dettman, R.W.; Sporn, P.H.; Wysolmerski, R.B.; Chew, T.L.
Myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells: a three-dimensional FRET study (2010), J. Cell Sci., 123, 431-440.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.11.18	Bos taurus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.11.18	endothelial cell	-	Bos taurus	-
2.7.11.18	pulmonary artery endothelial cell	-	Bos taurus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.11.18	ATP + myosin-II regulatory light chain	-	Bos taurus	ADP + myosin-II regulatory light chain phosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.11.18	MLCK	-	Bos taurus
2.7.11.18	myosin light chain kinase	-	Bos taurus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.7.11.18	ATP	-	Bos taurus

Expression

EC Number	Organism	Comment	Expression
2.7.11.18	Bos taurus	breast cancer cells transiently activate endothelial MLCK at tumor invasion sites	up

General Information

EC Number	General Information	Comment	Organism
2.7.11.18	physiological function	myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells	Bos taurus

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Release 2023.1 (January 2023)