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Literature summary extracted from

  • Golden, A.; Liu, J.; Cohen-Fix, O.
    Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope (2009), J. Cell Sci., 122, 1970-1978.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.4 lpin-1 coding sequences (with introns) and 3' UTR sequences amplified and recombined into pDONR P1P3. Final product pAG-107 reacted with pCR319 (contains the unc-119(+) gene for transformation rescue of unc-119(ed3) mutants) and pAG-108 (including the lpin-1 promoter) to produce pAG-126 Caenorhabditis elegans

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Caenorhabditis elegans
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-
-

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 lipin
-
 Caenorhabditis elegans
3.1.3.4 phosphatidic acid phosphohydrolase
-
 Caenorhabditis elegans

Expression

EC Number Organism Comment Expression
3.1.3.4 Caenorhabditis elegans downregulation of LPIN-1 by RNAi down

General Information

EC Number General Information Comment Organism
3.1.3.4 malfunction downregulating LPIN-1 by RNAi results in the appearance of membrane sheets and other abnormal structures in the peripheral endoplasmic reticulum. Lpin-1 RNAi causes defects in nuclear envelope breakdown, abnormal chromosome segregation and irregular nuclear morphology. RNAi of lipin results in reduced body size and defects in lipid storage Caenorhabditis elegans
3.1.3.4 physiological function lipin is needed for lipid storage and development. Lipin activity is needed for normal nuclear structure in dividing cells Caenorhabditis elegans