EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.137 | LY294002 | - |
Homo sapiens | |
2.7.1.137 | Wortmannin | - |
Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.137 | Mg2+ | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.137 | ATP + 1-phosphatidyl-1D-myo-inositol | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.137 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.137 | granulocyte | - |
Homo sapiens | - |
2.7.1.137 | NB-4 cell | a promyelocytic leukemia cell line, expression of different PI3K isoforms during granulocyte differentiation of NB4 cells induced by all-trans-retinoic acid, 9-cis-retinoic acid or retinoic acid receptor agonists, overview | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.137 | ATP + 1-phosphatidyl-1D-myo-inositol | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.137 | PI3-kinase | - |
Homo sapiens |
2.7.1.137 | PI3K | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.1.137 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.137 | 7.4 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.137 | ATP | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.137 | malfunction | Co-treatment of NB4 cells with either LY294002 to inhibit PI3Ks or PD98059 in order to suppress MEK activity lead to significant reduction of CD11b surface expression during all-trans-retinoic acid, 9-cis-retinoic acid or retinoic acid receptor agonist Ro40-6055 dependent NB4 cells granulocyte differentiation | Homo sapiens |
2.7.1.137 | physiological function | involvement of PI3K in all-trans-retinoic acid or Ro40-6055, a retinoic acid receptor alpha specific agonist, dependent granulocyte differentiation of NB4 cells, overview | Homo sapiens |