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Literature summary extracted from

  • Lucero, H.A.; Kintsurashvili, E.; Marketou, M.E.; Gavras, H.
    Cell signaling, internalization, and nuclear localization of the angiotensin converting enzyme in smooth muscle and endothelial cells (2010), J. Biol. Chem., 285, 5555-5568.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.15.1 extracellular
-
 Rattus norvegicus
-
-
3.4.15.1 additional information subcellular localization study, selective nuclear localization of ACE in smooth muscle cells and umbilical vein cells, HUVEC, may require the expression of specific protein receptors in these cells, overview. Mechanism of ACE endocytosis, overview Rattus norvegicus
-
-
3.4.15.1 nuclear envelope
-
 Rattus norvegicus 5635
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3.4.15.1 nucleus transcriptional regulation by exogenous ACE may involve its nuclear localization, nuclear localization of ACE is impaired by selective inhibitors of endocytosis Rattus norvegicus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.15.1 angiotensin I + H2O Rattus norvegicus i.e. DRVYIHPFHL angiotensin II + His-Leu i.e. DRVYIHPF ?
3.4.15.1 bradykinin + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.15.1 native enzyme, nucleus preparation, gel filtration Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 aorta
-
 Rattus norvegicus
-
3.4.15.1 endothelial cell
-
 Rattus norvegicus
-
3.4.15.1 kidney
-
 Rattus norvegicus
-
3.4.15.1 smooth muscle cell from aorta, extracellular ACE binds to smooth muscle cells, overview Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O i.e. DRVYIHPFHL Rattus norvegicus angiotensin II + His-Leu i.e. DRVYIHPF ?
3.4.15.1 bradykinin + H2O
-
 Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.15.1 More ACE contains transactivation domains in its sequence Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 ACE
-
 Rattus norvegicus
3.4.15.1 angiotensin converting enzyme
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.15.1 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.15.1 7.5 7.9 assay at Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.4.15.1 physiological function ACE catalyzes the extracellular formation of angiotensin II, and degradation of bradykinin, thus regulating blood pressure and renal handling of electrolytes. ACE added to smooth muscle cells resultes in transcriptional stimulation of the genes of bradykinin receptors B1 and B2. ACE enhances the activation of platelet-derived growth factor receptor beta signaling pathway Rattus norvegicus