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Literature summary extracted from

  • Newcomer, M.E.; Gilbert, N.C.
    Location, location, location: compartmentalization of early events in leukotriene biosynthesis (2010), J. Biol. Chem., 285, 25109-25114.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.4.1.20 X-ray structure refined to 2.15 A resolution Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.20 leukotriene C4 leukotriene C4 accumulation inhibits LTC4 synthase activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.4.1.20 membrane is localized to the outer nuclear membrane, is associated with 5-lipoxygenase activating protein and 5-lipoxygenase. Exclusion from the inner nuclear membrane Homo sapiens 16020
-
4.4.1.20 nucleus
-
 Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.20 Homo sapiens Q16873
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.20 leukotriene A4 + glutathione
-
 Homo sapiens leukotriene C4
-
 ?

Subunits

EC Number Subunits Comment Organism
4.4.1.20 trimer crystallography Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
4.4.1.20 leukotriene C4 synthase
-
 Homo sapiens
4.4.1.20 LTC4S
-
 Homo sapiens