EC Number | Application | Comment | Organism |
---|---|---|---|
3.3.2.10 | drug development | the enzyme is a promising target for drug development | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.3.2.10 | Y383F | site-directed mutagenesis, the mutant shows abolished sEH activity | Mus musculus |
3.3.2.10 | Y383F | site-directed mutagenesis, the mutant shows abolished sEH activity | Homo sapiens |
3.3.2.10 | Y466F | site-directed mutagenesis, the mutant shows abolished sEH activity | Mus musculus |
3.3.2.10 | Y466F | site-directed mutagenesis, the mutant shows abolished sEH activity | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.3.2.10 | 3-morpholinosydnonimine | i.e. SIN-1, a peroxonitrite generator, causes nitration on several tyrosine residues including Tyr383 and Tyr466. 1-adamantyl-3-cyclohexylurea in vitro decreases sensitivity to SIN-1 | Homo sapiens | |
3.3.2.10 | 3-morpholinosydnonimine | i.e. SIN-1, a peroxonitrite generator, causes nitration on several tyrosine residues including Tyr383 and Tyr466. 1-adamantyl-3-cyclohexylurea in vitro decreases sensitivity to SIN-1 | Mus musculus | |
3.3.2.10 | peroxynitrite | causes nitration on several tyrosine residues including Tyr383 and Tyr466 | Homo sapiens | |
3.3.2.10 | peroxynitrite | causes nitration on several tyrosine residues including Tyr383 and Tyr466 | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.3.2.10 | cytosol | - |
Mus musculus | 5829 | - |
3.3.2.10 | cytosol | - |
Homo sapiens | 5829 | - |
3.3.2.10 | soluble | - |
Mus musculus | - |
- |
3.3.2.10 | soluble | - |
Homo sapiens | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.3.2.10 | (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
3.3.2.10 | (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Homo sapiens | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
3.3.2.10 | (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
3.3.2.10 | additional information | Mus musculus | activity of the sEH can be regulated by the tyrosine nitration of the protein | ? | - |
? | |
3.3.2.10 | additional information | Homo sapiens | activity of the sEH can be regulated by the tyrosine nitration of the protein | ? | - |
? | |
3.3.2.10 | additional information | Mus musculus C57BL/6 | activity of the sEH can be regulated by the tyrosine nitration of the protein | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.3.2.10 | Homo sapiens | P34913 | gene EPHX2 | - |
3.3.2.10 | Mus musculus | P34914 | C57BL/6 mice | - |
3.3.2.10 | Mus musculus C57BL/6 | P34914 | C57BL/6 mice | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.3.2.10 | endothelial cell | - |
Homo sapiens | - |
3.3.2.10 | endothelial cell | from lung | Mus musculus | - |
3.3.2.10 | HEK-293 cell | - |
Homo sapiens | - |
3.3.2.10 | HUVEC cell | - |
Homo sapiens | - |
3.3.2.10 | lung | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.3.2.10 | (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
3.3.2.10 | (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
3.3.2.10 | (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
3.3.2.10 | additional information | activity of the sEH can be regulated by the tyrosine nitration of the protein | Mus musculus | ? | - |
? | |
3.3.2.10 | additional information | activity of the sEH can be regulated by the tyrosine nitration of the protein | Homo sapiens | ? | - |
? | |
3.3.2.10 | additional information | activity of the sEH can be regulated by the tyrosine nitration of the protein | Mus musculus C57BL/6 | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.3.2.10 | SEH | - |
Mus musculus |
3.3.2.10 | SEH | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.3.2.10 | 37 | - |
assay at | Mus musculus |
3.3.2.10 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.3.2.10 | 7.2 | - |
assay at | Mus musculus |
3.3.2.10 | 7.2 | - |
assay at | Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.3.2.10 | malfunction | in vivo, streptozotocin-induced diabetes results in the tyrosine nitration of the sEH in murine lungs and a significant decrease in its activity. Inhibition of sEH has beneficial effects on vascular inflammation and hypertension | Mus musculus |
3.3.2.10 | malfunction | inhibition of sEH has beneficial effects on vascular inflammation and hypertension | Homo sapiens |