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Literature summary extracted from

  • Idkowiak-Baldys, J.; Baldys, A.; Raymond, J.R.; Hannun, Y.A.
    Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner (2009), J. Biol. Chem., 284, 22322-22331.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.4 expressed in C-6 glioma cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 1-butanol
-
 Homo sapiens
3.1.4.4 additional information no inhibition by 2-butanol Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.4 plasma membrane
-
 Homo sapiens 5886
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
-
 isozymes PLD1 and PLD2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 HEK-293 cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
-
 Homo sapiens
3.1.4.4 PLD1
-
 Homo sapiens
3.1.4.4 PLD2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.4.4 additional information stimulation of the serotonin 5-HT2A receptor and the angiotensin II receptor, AT1AR, two G-protein-coupled receptors, leads to their sequestration from endosomes to into a Rab11-positive juxtanuclear compartment in a PKC- and PLD-dependent manner, detailed overview. The PKC- and PLD-dependent sequestration of receptors results in co-sequestration of other plasma membrane proteins and receptors, e.g. of epidermal growth factor receptor and protease activated receptor-1 Homo sapiens