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Literature summary extracted from

  • Wang, J.; Rajput, A.; Kan, J.L.; Rose, R.; Liu, X.Q.; Kuropatwinski, K.; Hauser, J.; Beko, A.; Dominquez, I.; Sharratt, E.A.; Brattain, L.; Levea, C.; Sun, F.L.; Keane, D.M.; Gibson, N.W.; Brattain, M.G.
    Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma (2009), J. Biol. Chem., 284, 10912-10922.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.137 Ron kinase Ron plays an essential role in maintaining malignant phenotypes of colon cancer cells through regulating mutant PI3K activity Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.137 H1047R HCT-116 cells are heterozygous for gain of function mutant PIK3CA catalytic subunit Homo sapiens
2.7.1.137 additional information RNA interference-mediated knockdown of Ron kinase in a highly tumorigenic colon cancer HCT116 cell line leads to reduced proliferation as compared with the control cells and inhibits mutant phosphatidylinositol 3-kinase, phenotype, overview. Ron kinase knockout reduces metastasis in diverse human cancer cell lines, overview Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.137 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.137 colonic cancer cell
-
 Homo sapiens
-
2.7.1.137 HCT-116 cell HCT-116 cells are heterozygous for gain of function mutant PIK3CA H1047R Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.137 heterodimer the regulatory p85 subunit of PI3K stabilizes catalytic subunit p110, but also inhibits its lipid kinase activity Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.137 PI3K
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.137 22
-
 assay at room temperature Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.137 7.4
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.137 ATP
-
 Homo sapiens