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Literature summary extracted from

  • Samanta, K.; Kar, P.; Chakraborti, T.; Chakraborti, S.
    Calcium-dependent cleavage of the Na+/Ca2+ exchanger by m-calpain in isolated endoplasmic reticulum (2010), J. Biochem., 147, 225-235.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.53 calpastatin
-
 Bos taurus
3.4.22.53 calpeptin
-
 Bos taurus
3.4.22.53 EGTA
-
 Bos taurus
3.4.22.53 MDL28170
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.53 endoplasmic reticulum
-
 Bos taurus 5783
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.22.53 Ca2+ treatment of the endoplasmic reticulum with Ca2+ (5 mM) dissociates m-calpain-calpastatin association leading to the activation of m-calpain Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.53 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.53 ammonium sulfate precipitation, DEAE-cellulose column chromatography, phenyl-Sepharose column chromatography, Reactive Red column chromatography, and DEAE-TSK anion exchange column chromatography Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.53 pulmonary artery smooth muscle cell
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.53 Na+/Ca2+ exchanger + H2O
-
 Bos taurus 82000 Da fragment + ?
-
 ?
3.4.22.53 SLLVY-7-amido-4-methylcoumarin + H2O
-
 Bos taurus SLLVY + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.53 calpain 2
-
 Bos taurus
3.4.22.53 m-calpain
-
 Bos taurus