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Literature summary extracted from

  • Kajiwara, Y.; Santander, P.J.; Roessner, C.A.; Perez, L.M.; Scott, A.I.
    Genetically engineered synthesis and structural characterization of cobalt-precorrin 5A and -5B, two new intermediates on the anaerobic pathway to vitamin B12: definition of the roles of the CbiF and CbiG enzymes (2006), J. Am. Chem. Soc., 128, 9971-9978.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.7.1.12 synthesis synthesis of cobalt corrinoid intermediates cobalt-precorrin 5A and cobalt-precorrin 5B, with the aid of overexpressed enzymes of the vitamin B12 pathway of Salmonella enterica serovar typhimurium Salmonella enterica

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.271 Salmonella enterica
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3.7.1.12 Salmonella enterica
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.271 S-adenosyl-L-methionine + cobalt-precorrin-4 isoform CbiF is the SAM-cobalt-precorrin 4 methyl transferase which methylates the C-11 position, the product can be named cobalt-precorrin 5A. The enzyme has a high degree of nonspecificity and methylates several closely related porphyrinoids at this R-position Salmonella enterica S-adenosyl-L-homocysteine + cobalt-precorrin-5A
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Synonyms

EC Number Synonyms Comment Organism
2.1.1.271 CbiF
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Salmonella enterica

General Information

EC Number General Information Comment Organism
3.7.1.12 physiological function CbiG is the gene product responsible for the opening of the ring A delta-lactone and extrusion of the C2 unit. The anaerobic biosynthetic pathway features internal delivery of oxygen from a carboxylic acid terminus to C-20 followed by extrusion of the C2 unit as acetaldehyde, using cobalt complexes as substrates Salmonella enterica