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Literature summary extracted from
- Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization (2009), J. Allergy Clin. Immunol., 124, 724-730.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.4.1.20 | medicine | aspirin desensitization may provide effective therapy for aspirin-exacerbated respiratory disease, at least in part, through mitigation of STAT6 expression, thereby downregulating LTC4S pathways | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.20 | aspirin | blocks the STAT6-dependent interleukin-4-inducible expression of LTC4S | Homo sapiens |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.4.1.20 | Homo sapiens | Q16873 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.4.1.20 | THP-1 cell | - |
Homo sapiens | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.4.1.20 | leukotriene C4 synthase | - |
Homo sapiens |
| 4.4.1.20 | LTC4 synthase | - |
Homo sapiens |
| 4.4.1.20 | LTC4S | - |
Homo sapiens |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 4.4.1.20 | Homo sapiens | no upregulation by interleukin-4 in the THP-1 cell line | down |
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Release 2023.1 (January 2023)
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