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Literature summary extracted from
- Flavonoids from the buds of Rosa damascena inhibit the activity of 3-hydroxy-3-methylglutaryl-coenzyme a reductase and angiotensin I-converting enzyme (2010), J. Agric. Food Chem., 58, 882-886.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | captopril | - |
Oryctolagus cuniculus |  |
| 3.4.15.1 | cyanidin-3-O-beta-D-glucoside | isolated from flower buds of Rosa damascena. Metal ions might be involved in the inhibition | Oryctolagus cuniculus | |
| 3.4.15.1 | additional information | no inhibition by flavonoid glycosides, isolated from flower buds of Rosa damascena, kaempferol-3-O-beta-D-glucopyranosyl-(1,4)-beta-D-xylopyranoside, i.e. roxyloside A, isoquercitrin, quercetin gentiobioside, and afzelin | Oryctolagus cuniculus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | commercial preparation | - |
Oryctolagus cuniculus | - |
| 3.4.15.1 | lung | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | hippuryl-His-Leu + H2O | - |
Oryctolagus cuniculus | hippuric acid + His-Leu | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | ACE | - |
Oryctolagus cuniculus |
| 3.4.15.1 | angiotensin I-converting enzyme | - |
Oryctolagus cuniculus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.15.1 | 37 | - |
assay at | Oryctolagus cuniculus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.15.1 | 8.3 | - |
assay at | Oryctolagus cuniculus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.15.1 | 0.0000092 | - |
pH 8.3, 37°C | Oryctolagus cuniculus | captopril | |
| 3.4.15.1 | 0.1388 | - |
pH 8.3, 37°C | Oryctolagus cuniculus | cyanidin-3-O-beta-D-glucoside | |
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Release 2023.1 (January 2023)
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