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Literature summary extracted from
- Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract (2010), J. Agric. Food Chem., 58, 4141-4144.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.9 | 3,4-dicaffeoylquinic acid | - |
Homo sapiens |  |
| 3.1.3.9 | 4,5-dicaffeoylquinic acid | - |
Homo sapiens | |
| 3.1.3.9 | 4-caffeoylquinic acid | - |
Homo sapiens | |
| 3.1.3.9 | 5-caffeoylquinic acid | - |
Homo sapiens | |
| 3.1.3.9 | Svetol | commercial unroasted and decaffeinated green Coffea canephora extract, competive inhibition | Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.3.9 | 2.41 | - |
D-glucose 6-phosphate | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.3.9 | microsome | - |
Homo sapiens | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.9 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.3.9 | liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.3.9 | 0.095 | - |
liver microsomes | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.9 | D-glucose 6-phosphate + H2O | - |
Homo sapiens | D-glucose + phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.3.9 | glucose-6-phosphatase | - |
Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.1.3.9 | additional information | - |
12.8% inhibition at 0.038 mM | Homo sapiens | 4,5-dicaffeoylquinic acid | |
| 3.1.3.9 | additional information | - |
14.4% inhibition at 0.12 mM | Homo sapiens | 4-caffeoylquinic acid | |
| 3.1.3.9 | additional information | - |
36% inhibition at 0.6 mM | Homo sapiens | Svetol | |
| 3.1.3.9 | additional information | - |
6.9% inhibition at 0.033 mM | Homo sapiens | 3,4-dicaffeoylquinic acid | |
| 3.1.3.9 | additional information | - |
9.2% inhibition at 0.16 mM | Homo sapiens | 5-caffeoylquinic acid | |
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Release 2023.1 (January 2023)
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