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Literature summary extracted from

  • Peltz, A.; Sherwani, S.I.; Kotha, S.R.; Mazerik, J.N.; O'Connor Butler, E.S.; Kuppusamy, M.L.; Hagele, T.; Magalang, U.J.; Kuppusamy, P.; Marsh, C.B.; Parinandi, N.L.
    Calcium and calmodulin regulate mercury-induced phospholipase D activation in vascular endothelial cells (2009), Int. J. Toxicol., 28, 190-206.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 Hg2+ mercury chloride, and methylmercury, activates PLD, the stimulation is regulated by Ca2+ and calmodulin, mechanism, overview. Calcium chelating agents and calcium depletion, e.g. by EGTA, calmodulin inhibitors, e.g. calmidazolium chloride and trifluoperazine, and L-type calcium channel blockers nifedipine, nimodipine, and diltiazem attenuate the stimulation of PLD by mercury, overview Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 vascular endothelial cell from pulmonary artery Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 additional information PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor Bos taurus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.4 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.4 7.4
-
 assay at Bos taurus

General Information

EC Number General Information Comment Organism
3.1.4.4 physiological function PLD generates bioactive lipid second messengers in vascular endothelial cells Bos taurus