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Literature summary extracted from

  • Juhasz, T.; Matta, C.; Veress, G.; Nagy, G.; Szijgyarto, Z.; Molnar, Z.; Fodor, J.; Zakany, R.; Gergely, P.
    Inhibition of calcineurin by cyclosporine A exerts multiple effects on human melanoma cell lines HT168 and WM35 (2009), Int. J. Oncol., 34, 995-1003.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.16 Calmodulin calcineurin is dependent on Ca2+/calmodulin Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 cyclosporin A a specific pharmacological inhibitor of calcineurin. Cyclosporin A modulates cell shape and actin organization of melanoma cells Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.16 Ca2+ calcineurin is dependent on Ca2+/calmodulin Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.16 HT-168 cell selected from A2058 cell line Homo sapiens
-
3.1.3.16 melanoma cell
-
 Homo sapiens
-
3.1.3.16 WM-35 cell established from a primary cutaneous melanoma of radial growth phase Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 phosphorylated protein phosphatase inhibitor-1 + H2O
-
 Homo sapiens protein phosphatase inhibitor-1 + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 calcineurin
-
 Homo sapiens
3.1.3.16 PP2B
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.3.16 malfunction partly malignancy-dependent role of calcineurin in melanoma cell lines, overview. Calcineurin-inhibiting compounds are applied for local treatment of psoriasis or atopic dermatitis Homo sapiens