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Literature summary extracted from

  • Shim, S.M.; Kwon, H.
    Metabolites of amygdalin under simulated human digestive fluids (2010), Int. J. Food Sci. Nutr., 61, 770-779.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.2.1.117 diagnostics evaluating intestinal absorption of amygdalin or prunasin, by estimating its transfer across the mucosal border as well as its uptake into the intestinal tissue, for judgement of toxication rusks, overview. Use of the enzyme in an in vitro digestion model with the Caco-2 cell to estimate the human oral bioavailability of cyanogenic compounds from food or plants, overview Homo sapiens
3.2.1.118 diagnostics evaluating intestinal absorption of amygdalin or prunasin, by estimating its transfer across the mucosal border as well as its uptake into the intestinal tissue, for judgement of toxication rusks, overview. Use of the enzyme in an in vitro digestion model with the Caco-2 cell to estimate the human oral bioavailability of cyanogenic compounds from food or plants, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.117 (R)-amygdalin + H2O Homo sapiens amygdalin is decomposed by beta-glucosidase in the digestive fluid into glucose and prunasin, which is further hydrolyzed to mandelonitrile and then to benzaldehyde and hydrogen cyanide. Amygdalin, a toxic component, can cause fatal cyanide poisonings, chronic toxicity, and death (R)-prunasin + D-glucose
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 ?
3.2.1.118 prunasin + H2O Homo sapiens prunasin is taken up in the small intestine and decomposed by beta-glucosidase into glucose and mandelonitrile, which is further hydrolyzed to benzaldehyde and hydrogen cyanide. Amygdalin, the precursor of prunasin, is a toxic component and can cause fatal cyanide poisonings, chronic toxicity, and death D-mandelonitrile + beta-D-glucose
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.117 Homo sapiens
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-
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3.2.1.118 Homo sapiens
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.117 Caco-2 cell TC7 clone Homo sapiens
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3.2.1.117 digestive juice
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 Homo sapiens
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3.2.1.117 small intestine use of a simulated in vitro salivary-gastric-small intestinal digestion model system Homo sapiens
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3.2.1.118 Caco-2 cell TC7 clone Homo sapiens
-
3.2.1.118 digestive juice
-
 Homo sapiens
-
3.2.1.118 small intestine use of a simulated in vitro salivary-gastric-small intestinal digestion model system Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.117 (R)-amygdalin + H2O amygdalin is decomposed by beta-glucosidase in the digestive fluid into glucose and prunasin, which is further hydrolyzed to mandelonitrile and then to benzaldehyde and hydrogen cyanide. Amygdalin, a toxic component, can cause fatal cyanide poisonings, chronic toxicity, and death Homo sapiens (R)-prunasin + D-glucose
-
 ?
3.2.1.117 (R)-amygdalin + H2O substrate and product determination in the in vitro system by mass spectrometry, method, overview Homo sapiens (R)-prunasin + D-glucose
-
 ?
3.2.1.118 prunasin + H2O prunasin is taken up in the small intestine and decomposed by beta-glucosidase into glucose and mandelonitrile, which is further hydrolyzed to benzaldehyde and hydrogen cyanide. Amygdalin, the precursor of prunasin, is a toxic component and can cause fatal cyanide poisonings, chronic toxicity, and death Homo sapiens D-mandelonitrile + beta-D-glucose
-
 ?
3.2.1.118 prunasin + H2O substrate and product determination in the in vitro system by mass spectrometry, method, overview Homo sapiens D-mandelonitrile + beta-D-glucose
-
 ?