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Literature summary extracted from

  • D'Eliseo, D.; Pisu, P.; Romano, C.; Tubaro, A.; De Nunzio, C.; Morrone, S.; Santoni, A.; Stoppacciaro, A.; Velotti, F.
    Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion (2009), Int. J. Cancer, 127, 1283-1294.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.79 Z-Ala-Ala-Asp-CH2Cl
-
Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.79 35000
-
Western blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.79 Vitronectin + H2O Homo sapiens Grb expressed in human bladder cancer cell lines 1512 and RT112 cleave vitronectin ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.79 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.79 bladder GrB is expressed in 7 out of 12 bladder cancer cell lines Homo sapiens
-
3.4.21.79 urothelium GrB is expressed, in absence of perforin in urothelial carcinoma cells. Significant differences are found between GrB expression and both increasing pathological tumor spreading and high-grade vs. low-grade pTa tumors Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.79 Ace-Ile-Glu-Pro-Asp-p-nitroanilide + H2O
-
Homo sapiens Ace-Ile-Glu-Pro-Asp + p-nitroaniline
-
?
3.4.21.79 Vitronectin + H2O Grb expressed in human bladder cancer cell lines 1512 and RT112 cleave vitronectin Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.79 granzyme B
-
Homo sapiens
3.4.21.79 GrB
-
Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.21.79 Homo sapiens GrB in urothelial cancer tissues is concentrated at the cancer invasion front and is expressed in neoplastic cells undergoing epithelial-mesenchymal transition, a key event in carcinoma invasion up

General Information

EC Number General Information Comment Organism
3.4.21.79 malfunction inhibition or downregulation of GrB suppresses bladder cancer cell invasion in vitro Homo sapiens
3.4.21.79 physiological function GrB, via extracellular matrix degradation, contributes to the establishment of the urothelial carcinoma invasive phenotype Homo sapiens