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Literature summary extracted from

  • Desiniotis, A.; Schaefer, G.; Klocker, H.; Eder, I.E.
    Enhanced antiproliferative and proapoptotic effects on prostate cancer cells by simultaneously inhibiting androgen receptor and cAMP-dependent protein kinase A (2010), Int. J. Cancer, 126, 775-789.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Homo sapiens
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 DU-145 cell
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Homo sapiens
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2.7.11.11 LNCaP cell
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Homo sapiens
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2.7.11.11 prostate cancer cell line
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Homo sapiens
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Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 cyclic AMP-dependent protein kinase A
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Homo sapiens
2.7.11.11 PKA
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Homo sapiens
2.7.11.11 PKA RIalpha regulatory subunit I alpha of PKA Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
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Homo sapiens
2.7.11.11 cAMP
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Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.11.11 malfunction combined inhibition of the androgen receptor and the regulatory subunit I alpha of PKA with small interference RNAs significantly increases the growth-inhibitory and proapoptotic effects of androgen receptor knockdown. Downregulating PKA RIalpha is sufficient to inhibit PKA signaling and also impairs androgen receptor expression and activation. Depletion of PKA RIalpha also potentiates the antiproliferative effect of the antiandrogen bicalutamide in androgen-sensitive LNCaP cells Homo sapiens