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Literature summary extracted from

  • Hwang, M.K.; Song, N.R.; Kang, N.J.; Lee, K.W.; Lee, H.J.
    Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: its direct inhibition by quercetin (2009), Int. J. Biochem. Cell Biol., 41, 1592-1600.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.153 TNF-alpha activates PI3K Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.153 LY294002 a specific #PI3K inhibitor Mus musculus
2.7.1.153 quercetin from red wine extract, quercetin and red wine polyphenol extract inhibit the phosphorylation of Akt in vivo and show inhibitory effects on TNF-alpha-induced upregulation of MMP-9 and on the migratory phenotype of JB6 P+ mouse epidermal, mediated by suppression of the phosphorylation of Akt and the transactivation of activator protein-1 and nuclear factor-kappaB. Red wine extract and quercetin suppress TNF-alpha-induced PI3K activity by binding specifically to PI3K Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.153 plasma membrane
-
 Mus musculus 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.153 Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Mus musculus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate phosphatidylinositol-3,4,5-triphosphate is a major product of active PI3K, and recruits Akt/PKB to the plasma membrane and the phosphorylation of Akt occurs ?
2.7.1.153 ATP + Akt Mus musculus
-
 ADP + Akt phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.153 Mus musculus
-
-
-
3.4.24.35 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.153 JB6 cell
-
 Mus musculus
-
3.4.24.35 JB6 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate
-
 ?
2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate phosphatidylinositol-3,4,5-triphosphate is a major product of active PI3K, and recruits Akt/PKB to the plasma membrane and the phosphorylation of Akt occurs ?
2.7.1.153 ATP + Akt
-
 Mus musculus ADP + Akt phosphate
-
 ?
3.4.24.35 Gelatin + H2O
-
 Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.153 PI3K
-
 Mus musculus
3.4.24.35 matrix metalloproteinase-9
-
 Mus musculus
3.4.24.35 MMP-9
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.153 30
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.153 7.6
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.153 ATP
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.4.24.35 Mus musculus activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9. Red wine extrac and quercetin inhibit significantly the tumor necrosis factor-alpha-induced upregulation of MMP-9 whereas resveratrol does not have significant inhibitory effects up

General Information

EC Number General Information Comment Organism
2.7.1.153 physiological function activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9 Mus musculus