EC Number | Application | Comment | Organism |
---|---|---|---|
3.4.18.1 | diagnostics | Cathepsin X is an inflammatory marker | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.18.1 | expression of the proenzyme in Pichia pastoris | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.18.1 | bradykinin + H2O | Homo sapiens | the peptide is converted from a bradykinin B2 receptor ligand to a bradykinin B1 receptor specific ligand | ? | - |
? | |
3.4.18.1 | kallidin + H2O | Homo sapiens | the peptide is converted from a bradykinin B2 receptor ligand to a bradykinin B1 receptor specific ligand | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.18.1 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.18.1 | proteolytic modification | processing of the recombinant proenzyme by cathepsin L | Homo sapiens |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.18.1 | recombinant enzyme from Pichia pastoris by cation exchange chromatography | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.18.1 | bradykinin + H2O | i.e. Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, a mainly B2 receptor | Homo sapiens | Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + Arg | an exclusive B1 receptor | ? | |
3.4.18.1 | bradykinin + H2O | the peptide is converted from a bradykinin B2 receptor ligand to a bradykinin B1 receptor specific ligand | Homo sapiens | ? | - |
? | |
3.4.18.1 | kallidin + H2O | the peptide is converted from a bradykinin B2 receptor ligand to a bradykinin B1 receptor specific ligand | Homo sapiens | ? | - |
? | |
3.4.18.1 | kallidin + H2O | i.e. Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, a mainly B2 receptor | Homo sapiens | Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + Arg | an exclusive B1 receptor | ? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.18.1 | 5.5 | - |
assay at | Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.18.1 | physiological function | cathepsin X generates peptide receptor agonists and acts as a type I kininase. It is a cysteine-type carboxypeptidase and able to modulate the kallikreinkinin system through carboxyterminal processing of the small peptide hormones bradykinin and kallidin. Cathepsin X as an alternative possible link between the kallikreinkinin system and the reninangiotensin system in that it not only cleaves kinins C-terminally, but also converts angiotensin I to angiotensin II, reaction of EC 3.6.15.1 | Homo sapiens |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.18.1 | 4.17 | - |
bradykinin | pH 5.5 | Homo sapiens | |
3.4.18.1 | 5.75 | - |
kallidin | pH 5.5 | Homo sapiens |