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Literature summary extracted from

  • Naegler, D.K.; Kraus, S.; Feierler, J.; Mentele, R.; Lottspeich, F.; Jochum, M.; Faussner, A.
    A cysteine-type carboxypeptidase, cathepsin X, generates peptide receptor agonists (2010), Int. Immunopharmacol., 10, 134-139.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.18.1 diagnostics Cathepsin X is an inflammatory marker Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.18.1 expression of the proenzyme in Pichia pastoris Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.18.1 bradykinin + H2O Homo sapiens the peptide is converted from a bradykinin B2 receptor ligand to a bradykinin B1 receptor specific ligand ?
-
?
3.4.18.1 kallidin + H2O Homo sapiens the peptide is converted from a bradykinin B2 receptor ligand to a bradykinin B1 receptor specific ligand ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.18.1 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.18.1 proteolytic modification processing of the recombinant proenzyme by cathepsin L Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.18.1 recombinant enzyme from Pichia pastoris by cation exchange chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.18.1 bradykinin + H2O i.e. Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, a mainly B2 receptor Homo sapiens Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + Arg an exclusive B1 receptor ?
3.4.18.1 bradykinin + H2O the peptide is converted from a bradykinin B2 receptor ligand to a bradykinin B1 receptor specific ligand Homo sapiens ?
-
?
3.4.18.1 kallidin + H2O the peptide is converted from a bradykinin B2 receptor ligand to a bradykinin B1 receptor specific ligand Homo sapiens ?
-
?
3.4.18.1 kallidin + H2O i.e. Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, a mainly B2 receptor Homo sapiens Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + Arg an exclusive B1 receptor ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.18.1 5.5
-
assay at Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.18.1 physiological function cathepsin X generates peptide receptor agonists and acts as a type I kininase. It is a cysteine-type carboxypeptidase and able to modulate the kallikrein–kinin system through carboxyterminal processing of the small peptide hormones bradykinin and kallidin. Cathepsin X as an alternative possible link between the kallikrein–kinin system and the renin–angiotensin system in that it not only cleaves kinins C-terminally, but also converts angiotensin I to angiotensin II, reaction of EC 3.6.15.1 Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.4.18.1 4.17
-
bradykinin pH 5.5 Homo sapiens
3.4.18.1 5.75
-
kallidin pH 5.5 Homo sapiens