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Literature summary extracted from

  • Danford, J.J.; Dobrowolski, P.; Berreau, L.M.
    Thioester hydrolysis reactivity of an Fe(III)Zn(II) complex (2009), Inorg. Chem., 48, 11352-11361.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.2.6 additional information the Fe(III)Zn(II) complex [(2-{[bis(2-pyridylmethyl)amino]methyl}-6-[{[2-hydroxyphenyl)methyl]-(2-pyridylmethyl)amino}methyl]-4-methylphenolFe(III)Zn(II)(micro-O2C2H3)2]ClO4 promotes thioester hydrolysis Arabidopsis thaliana

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.2.6 Fe3+ thioester hydrolysis is promoted by an Fe(III)Zn(II) complex. Thioester does not initially interact with the Fe(III) center, changes occur at this site over the course of the reaction. Formation of a Fe(III)-S-methyl ester moiety, which likely results from redox activity involving an iron(III) thiolate species. Thioester hydrolysis may involve initial coordination of the deprotonated alpha-hydroxy thioester to the zinc center followed by nucleophilic attack by a terminal Fe(III)-OH moiety and thiolate leaving group stabilization by the Fe(III) center Arabidopsis thaliana
3.1.2.6 Zn2+ thioester hydrolysis is promoted by an Fe(III)Zn(II) complex. Thioester hydrolysis may involve initial coordination of the deprotonated alpha-hydroxy thioester to the zinc center followed by nucleophilic attack by a terminal Fe(III)-OH moiety and thiolate leaving group stabilization by the Fe(III) center Arabidopsis thaliana

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.6 Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.6 S-methyl hydroxy(phenyl)ethanethioate + H2O thioester hydrolysis is promoted by an Fe(III)Zn(II) complex Arabidopsis thaliana methanethiol + hydroxy(phenyl)acetic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.6 GlxII
-
 Arabidopsis thaliana
3.1.2.6 glyoxalase II
-
 Arabidopsis thaliana

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.2.6 6.5
-
 saturation kinetic behavior for the phosphate diester hydrolysis reaction Arabidopsis thaliana

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.2.6 7 9 saturation kinetic behavior for the thioester hydrolysis reaction. At pH 9.0 ligand exchange at the zinc center via deprotonation of the alpha-hydroxy group of the thioester to give an equilibrium amount of a zinc alkoxide species Arabidopsis thaliana