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Literature summary extracted from

  • Gulla, K.C.; Gupta, K.; Krarup, A.; Gal, P.; Schwaeble, W.J.; Sim, R.B.; OConnor, C.D.; Hajela, K.
    Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot (2010), Immunology, 129, 482-495.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.B7 ficolin
-
 Homo sapiens
3.4.21.B7 mannose-binding lectin
-
 Homo sapiens
3.4.21.104 ficolin
-
 Homo sapiens
3.4.21.104 mannose-binding lectin
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.B7 additional information hirudin does not inhibit MASP-1 Homo sapiens
3.4.21.B7 pefabloc i.e. 4-(2-aminoethyl)-benzenesulphonyl fluoride Homo sapiens
3.4.21.104 additional information hirudin does not inhibit MASP-2 Homo sapiens
3.4.21.104 pefabloc i.e. 4-(2-aminoethyl)-benzenesulphonyl fluoride Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.B7 87000
-
 MASP-1, gel filtration Homo sapiens
3.4.21.104 77000
-
 MASP-2, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B7 factor XIII + H2O Homo sapiens
-
 factor XIIIa + ?
-
 ?
3.4.21.B7 fibrinogen + H2O Homo sapiens
-
 fibrin + ?
-
 ?
3.4.21.B7 additional information Homo sapiens MBL-MASP complexes, bound to mannan-agarose, generate clots when incubated with calcified plasma or purified fibrinogen and factor XIII ?
-
 ?
3.4.21.B7 prothrombin + H2O Homo sapiens
-
 thrombin + ?
-
 ?
3.4.21.104 factor XIII + H2O Homo sapiens
-
 factor XIIIa + ?
-
 ?
3.4.21.104 fibrinogen + H2O Homo sapiens
-
 fibrin + ?
-
 ?
3.4.21.104 additional information Homo sapiens MBL-MASP complexes, bound to mannan-agarose, generate clots when incubated with calcified plasma or purified fibrinogen and factor XIII ?
-
 ?
3.4.21.104 prothrombin + H2O Homo sapiens
-
 thrombin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B7 Homo sapiens
-
-
-
3.4.21.104 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.B7 mannan-agarose column chromatography Homo sapiens
3.4.21.104 mannan-agarose column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B7 blood plasma
-
 Homo sapiens
-
3.4.21.104 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B7 factor XIII + H2O
-
 Homo sapiens factor XIIIa + ?
-
 ?
3.4.21.B7 fibrinogen + H2O
-
 Homo sapiens fibrin + ?
-
 ?
3.4.21.B7 additional information MBL-MASP complexes, bound to mannan-agarose, generate clots when incubated with calcified plasma or purified fibrinogen and factor XIII Homo sapiens ?
-
 ?
3.4.21.B7 prothrombin + H2O
-
 Homo sapiens thrombin + ?
-
 ?
3.4.21.104 factor XIII + H2O
-
 Homo sapiens factor XIIIa + ?
-
 ?
3.4.21.104 fibrinogen + H2O
-
 Homo sapiens fibrin + ?
-
 ?
3.4.21.104 additional information MBL-MASP complexes, bound to mannan-agarose, generate clots when incubated with calcified plasma or purified fibrinogen and factor XIII Homo sapiens ?
-
 ?
3.4.21.104 prothrombin + H2O
-
 Homo sapiens thrombin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B7 mannan-binding lectin-associated serine protease
-
 Homo sapiens
3.4.21.B7 MASP-1
-
 Homo sapiens
3.4.21.B7 MBL-MASP
-
 Homo sapiens
3.4.21.104 mannan-binding lectin-associated serine protease
-
 Homo sapiens
3.4.21.104 Map19 MASP-2 exists in an alternatively spliced form, known as Map19 Homo sapiens
3.4.21.104 MASP-2
-
 Homo sapiens
3.4.21.104 MBL-MASP
-
 Homo sapiens