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Literature summary extracted from

  • Tashiro, K.; Takai, S.; Jin, D.; Yamamoto, H.; Komeda, K.; Hayashi, M.; Tanaka, K.; Tanigawa, N.; Miyazaki, M.
    Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet (2010), Hepatol. Res., 40, 514-523.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.39 2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]thiazole-4-carboxylic acid TY-51469, specific chymase inhibitor Mesocricetus auratus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.39 Mesocricetus auratus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.39 liver
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.39 angiotensin I + H2O
-
 Mesocricetus auratus angiotensin II + ?
-
 ?
3.4.21.39 pro-matrix metalloprotease 9 + H2O
-
 Mesocricetus auratus matrix metalloprotease 9 + ?
-
 ?

General Information

EC Number General Information Comment Organism
3.4.21.39 physiological function chymase may play a crucial role in the development of nonalcoholic steatohepatitis in hamsters Mesocricetus auratus