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Literature summary extracted from
- Plumbagin inhibits invasion and migration of liver cancer HepG2 cells by decreasing productions of matrix metalloproteinase-2 and urokinase-plasminogen activator (2009), Hepatol. Res., 39, 998-1009.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.73 | semiquantitative reverse transcription PCR expression analysis of uPA and uPAR, overview | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.73 | Plumbagin | leads to uPA inhibition and downregulation, inhibits adhesion, migration and invasion in HepG2 cells | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.73 | plasminogen + H2O | Homo sapiens | - |
plasmin + ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.73 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.73 | Hep-G2 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.73 | plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? | |
| 3.4.21.73 | plasminogen + H2O | casein-plasminogen zymography assay method | Homo sapiens | plasmin + ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.73 | urokinase-plasminogen activator | - |
Homo sapiens |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 3.4.21.73 | Homo sapiens | plumbagin induces the enzyme expression in Hep-G2 cells, liver carcinoma cells, also inhibiting the invasion and migration of the cancer cells, overview | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.21.73 | malfunction | uPA is involved in adhesion, migration and invasion of hepatic Hep-G2 cancer cells, inhibition and downregulation of uPA by plumbagin also leads to inhibition of adhesion, migration and invasion by plumbagin in HepG2 cells, overview | Homo sapiens |
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Release 2023.1 (January 2023)
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