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Literature summary extracted from

  • Numakura, M.; Kusakabe, N.; Ishige, K.; Ohtake-Niimi, S.; Habuchi, H.; Habuchi, O.
    Preparation of chondroitin sulfate libraries containing disulfated disaccharide units and inhibition of thrombin by these chondroitin sulfates (2010), Glycoconj. J., 27, 479-489.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.5 antithrombin
-
 Bos taurus
3.4.21.5 glycosaminoglycan AD17
-
 Bos taurus
3.4.21.5 glycosaminoglycan AD4 shows only small inhibitory activity toward thrombin and the inhibition does not proceed beyond 40% inhibition Bos taurus
3.4.21.5 glycosaminoglycan AD9 shows only small inhibitory activity toward thrombin and the inhibition does not proceed beyond 40% inhibition Bos taurus
3.4.21.5 glycosaminoglycan AE11 modest inhibitory effect on thrombin activity Bos taurus
3.4.21.5 glycosaminoglycan AE15
-
 Bos taurus
3.4.21.5 glycosaminoglycan AE29
-
 Bos taurus
3.4.21.5 glycosaminoglycan AE6 modest inhibitory effect on thrombin activity Bos taurus
3.4.21.5 glycosaminoglycan CS-D
-
 Bos taurus
3.4.21.5 glycosaminoglycan CS-E
-
 Bos taurus
3.4.21.5 glycosaminoglycan DE17
-
 Bos taurus
3.4.21.5 glycosaminoglycan DE2
-
 Bos taurus
3.4.21.5 glycosaminoglycan DE9
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.5 fibrinogen + H2O Bos taurus
-
 fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.5 Bos taurus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.5 fibrinogen + H2O
-
 Bos taurus fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.21.5 0.0001
-
-
 Bos taurus glycosaminoglycan CS-E
3.4.21.5 0.00015
-
-
 Bos taurus glycosaminoglycan DE17
3.4.21.5 0.00025
-
-
 Bos taurus glycosaminoglycan DE9
3.4.21.5 0.00055
-
-
 Bos taurus glycosaminoglycan DE2
3.4.21.5 0.0007
-
-
 Bos taurus glycosaminoglycan AD17
3.4.21.5 0.00092
-
-
 Bos taurus glycosaminoglycan AE29
3.4.21.5 0.00095
-
-
 Bos taurus glycosaminoglycan CS-D
3.4.21.5 0.0025
-
-
 Bos taurus glycosaminoglycan AE15
3.4.21.5 0.00429
-
 IC50 above 0.00429 mM Bos taurus glycosaminoglycan AE6
3.4.21.5 0.00429
-
 IC50 above 0.00429 mM Bos taurus glycosaminoglycan AE11
3.4.21.5 0.00429
-
 IC50 above 0.00429 mM Bos taurus glycosaminoglycan AD4
3.4.21.5 0.00429
-
 IC50 above 0.00429 mM Bos taurus glycosaminoglycan AD9