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Literature summary extracted from

  • Cunningham, O.; Campion, S.; Perry, V.H.; Murray, C.; Sidenius, N.; Docagne, F.; Cunningham, C.
    Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation (2009), Glia, 57, 1802-1814.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.73 additional information uPA transcription and activity is only markedly increased during chronic neurodegeneration, not during acute intracerebral lipopolysaccharide-induced or acute kainate-induced neurodegeneration. Increase in total plasminogen activation with progression of prion disease is apparent in both soluble and membrane fractions Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.73 quantitative uPA expression analysis Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.73 plasminogen activator inhibitor 1 i.e. PAI-1 Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.73 Ca2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.73 plasminogen + H2O Mus musculus
-
 plasmin + ?
-
 ?
3.4.21.73 plasminogen + H2O Mus musculus C57BL/6
-
 plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Mus musculus
-
 C57BL/6 mice
-
3.4.21.73 Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.73 brain from ME7-infected mice Mus musculus
-
3.4.21.73 microglia
-
 Mus musculus
-
3.4.21.73 additional information the uPA receptor, a GPI-linked cell surface protein, occurs in macrophages infiltrating the central nervous system, and in the cerebrospinal fluid during a number of CNS pathologies Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 plasminogen + H2O
-
 Mus musculus plasmin + ?
-
 ?
3.4.21.73 plasminogen + H2O
-
 Mus musculus C57BL/6 plasmin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.73 uPA
-
 Mus musculus
3.4.21.73 Urokinase plasminogen activator
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.73 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.73 7.6
-
 assay at Mus musculus

Expression

EC Number Organism Comment Expression
3.4.21.73 Mus musculus uPA transcription and activity is only markedly increased during chronic neurodegeneration, not during acute intracerebral lipopolysaccharide-induced or acute kainate-induced neurodegeneration. Increase in total plasminogen activation with progression of prion disease is apparent in both soluble and membrane fractions up

General Information

EC Number General Information Comment Organism
3.4.21.73 malfunction uPA transcription and activity is only markedly increased during chronic neurodegeneration, not during acute intracerebral lipopolysaccharide-induced or acute kainate-induced neurodegeneration. Increase in total plasminogen activation with progression of prion disease is apparent in both soluble and membrane fractions Mus musculus
3.4.21.73 metabolism involvement of the uPAR/uPA system in CNS function and pathology, overview Mus musculus