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Literature summary extracted from

  • Schaefer, M.; Pollex, T.; Hanna, K.; Tuorto, F.; Meusburger, M.; Helmm M.; Lyko, F.
    RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage (2010), Genes Dev., 24, 1590-1595.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.204 cytoplasm granular cytoplasmic distribution with minor signals in the nucleus. Large structures appear in the cytoplasm and in the nucleus upon heat stress Drosophila melanogaster 5737
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.204 S-adenosyl-L-methionine + cytosine38 in tRNA Drosophila melanogaster RNA methylation by Dnmt2 protects tRNAs against stress-induced cleavage S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.204 Drosophila melanogaster Q9U6H7
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.204 embryo
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 Drosophila melanogaster
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2.1.1.204 larva
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 Drosophila melanogaster
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2.1.1.204 ovary
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 Drosophila melanogaster
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2.1.1.204 S2 cell
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 Drosophila melanogaster
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2.1.1.204 testis
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 Drosophila melanogaster
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.204 S-adenosyl-L-methionine + cytosine38 in tRNA RNA methylation by Dnmt2 protects tRNAs against stress-induced cleavage Drosophila melanogaster S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA
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 ?
2.1.1.204 S-adenosyl-L-methionine + cytosine38 in tRNA methylation of cytosine 38 in the anti-codon lopp of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC). Other C38-containing tRNAs-including tRNAMet(ATG), tRNAGlu(CTC), and tRNAHis(GTG) are not detectably methylated in a Dnmt2-dependent manner Drosophila melanogaster S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.204 Dnmt2
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 Drosophila melanogaster

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.204 37
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 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.1.1.204 malfunction Drosophila Dnmt2 mutants show reduced viability under stress conditions, and Dnmt2 relocalizes to stress granules following heat shock Drosophila melanogaster
2.1.1.204 physiological function RNA methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease Drosophila melanogaster