Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Gettins, P.G.; Olson, S.T.
    Activation of antithrombin as a factor IXa and Xa inhibitor involves mitigation of repression rather than positive enhancement (2009), FEBS Lett., 583, 3397-3400.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.6 antithrombin allosteric activation of antithrombin as a factor IXa and Xa inhibitor requires binding of a high-affinity heparin pentasaccharide and involves mitigation of repression rather than positive enhancement, via a mechanism in which heparin activates antithrombin by mitigating an unfavorable surface interaction, by altering its nature, and by moving the attached proteinase away from the site of the unfavorable interaction through RCL expulsion, detailed overview Homo sapiens
3.4.21.22 additional information allosteric activation of antithrombin inhibits factor IXa Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.6 Homo sapiens
-
-
-
3.4.21.22 Homo sapiens
-
-
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.6 factor Xa
-
 Homo sapiens
3.4.21.22 factor IXa
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.6 physiological function factor Xa is part of the blood coagulation cascade Homo sapiens