EC Number | Cloned (Comment) | Organism |
---|---|---|
4.6.1.1 | expressed in Escherichia coli BL21(DE3)(pRep4) cells | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.1 | cyclic poly-phosphate 17 | - |
Mycobacterium tuberculosis | |
4.6.1.1 | cyclic triphosphate | - |
Mycobacterium tuberculosis | |
4.6.1.1 | diphosphate | - |
Mycobacterium tuberculosis | |
4.6.1.1 | additional information | class I AC is unaffected by up to 0.03 mM poly-phosphate 75 | Mycobacterium tuberculosis | |
4.6.1.1 | phosphate | - |
Mycobacterium tuberculosis | |
4.6.1.1 | poly-phosphate 16 | - |
Mycobacterium tuberculosis | |
4.6.1.1 | poly-phosphate 25 | - |
Mycobacterium tuberculosis | |
4.6.1.1 | poly-phosphate 30 | - |
Mycobacterium tuberculosis | |
4.6.1.1 | poly-phosphate 45 | - |
Mycobacterium tuberculosis | |
4.6.1.1 | poly-phosphate 68 | - |
Mycobacterium tuberculosis | |
4.6.1.1 | poly-phosphate 75 | - |
Mycobacterium tuberculosis | |
4.6.1.1 | Triphosphate | - |
Mycobacterium tuberculosis |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
4.6.1.1 | membrane | - |
Mycobacterium tuberculosis | 16020 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.1 | ATP | Mycobacterium tuberculosis | - |
3',5'-cyclic-AMP + diphosphate | - |
? | |
4.6.1.1 | ATP | Mycobacterium tuberculosis BCG 1721 | - |
3',5'-cyclic-AMP + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.6.1.1 | Mycobacterium tuberculosis | - |
- |
- |
4.6.1.1 | Mycobacterium tuberculosis BCG 1721 | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.6.1.1 | - |
Mycobacterium tuberculosis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.1 | ATP | - |
Mycobacterium tuberculosis | 3',5'-cyclic-AMP + diphosphate | - |
? | |
4.6.1.1 | ATP | - |
Mycobacterium tuberculosis BCG 1721 | 3',5'-cyclic-AMP + diphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.6.1.1 | AC Rv1625c | - |
Mycobacterium tuberculosis |
4.6.1.1 | class III adenylate cyclase | - |
Mycobacterium tuberculosis |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
4.6.1.1 | 0.000011 | - |
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C | Mycobacterium tuberculosis | poly-phosphate 75 | |
4.6.1.1 | 0.000012 | - |
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C | Mycobacterium tuberculosis | poly-phosphate 45 | |
4.6.1.1 | 0.000012 | - |
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C | Mycobacterium tuberculosis | poly-phosphate 68 | |
4.6.1.1 | 0.000018 | - |
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C | Mycobacterium tuberculosis | poly-phosphate 30 | |
4.6.1.1 | 0.00002 | - |
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C | Mycobacterium tuberculosis | Triphosphate | |
4.6.1.1 | 0.000027 | - |
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C | Mycobacterium tuberculosis | poly-phosphate 25 | |
4.6.1.1 | 0.000033 | - |
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C | Mycobacterium tuberculosis | cyclic poly-phosphate 17 | |
4.6.1.1 | 0.0001 | - |
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C | Mycobacterium tuberculosis | poly-phosphate 16 | |
4.6.1.1 | 0.00021 | - |
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C | Mycobacterium tuberculosis | diphosphate | |
4.6.1.1 | 0.002 | - |
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C | Mycobacterium tuberculosis | cyclic triphosphate | |
4.6.1.1 | 11 | - |
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C | Mycobacterium tuberculosis | phosphate |