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Literature summary extracted from

  • Glitsch, M.D.
    Activation of native TRPC3 cation channels by phospholipase D (2010), FASEB J., 24, 318-325.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 ARF protein small G proteins of the Rho and Arf families activate phospholipase D1 Rattus norvegicus
3.1.4.4 phosphatidylinositol-4,5-bisphosphate an essential cofactor for phospholipase D1 activity Rattus norvegicus
3.1.4.4 Rho protein small G proteins of the Rho and Arf families activate phospholipase D1. Small GTPases might be involved in the activation mechanism of TRPC3 in rat cerebellar Purkinje cells. Rho GTPases can activate phospholipase D1 through two mechanisms: direct binding to phospholipase D1 or activation of phosphatidylinositol-4,5-kinase, which triggers phosphatidylinositol-4,5-bisphosphate production, an essential cofactor for phospholipase D1 activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 1-butanol does not causes direct inhibition of TRPC3 channels, but causes blocking of phospholipase D which interferes with retrograde signaling, overview. Neither voltage-gated Ca2+-channels nor Ca2+-activated Cl channels are affected by 1-butanol Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.4 additional information ativation of mGluR1 leads to phospholipase D1 translocation in granule cells, activation of mGluR1 triggers migration and thus activation of PLD1 in a cell-specific manner in the cerebellum Rattus norvegicus
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 additional information Rattus norvegicus phospholipase D activates native TRPC3 cation channels after stimulation of G-protein-coupled type I glutamate receptors in the cerebellum. Small GTPases might be involved in the activation mechanism of TRPC3 in rat cerebellar Purkinje cells, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Rattus norvegicus
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 isozyme PLD1
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 brain
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 Rattus norvegicus
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3.1.4.4 cerebellar Purkinje cell
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 Rattus norvegicus
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3.1.4.4 cerebellum
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 Rattus norvegicus
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3.1.4.4 granule cell
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 Rattus norvegicus
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3.1.4.4 neuron
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 Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 additional information phospholipase D activates native TRPC3 cation channels after stimulation of G-protein-coupled type I glutamate receptors in the cerebellum. Small GTPases might be involved in the activation mechanism of TRPC3 in rat cerebellar Purkinje cells, overview Rattus norvegicus ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 phospholipase D1
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 Rattus norvegicus
3.1.4.4 PLD-1
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 Rattus norvegicus
3.1.4.4 PLD1
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 Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.1.4.4 physiological function key role for phospholipase D in the generation of the slow excitatory postsynaptic current in cerebellar Purkinje cells Rattus norvegicus