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Literature summary extracted from

  • Lagente, V.; Le Quement, C.; Boichot, E.
    Macrophage metalloelastase (MMP-12) as a target for inflammatory respiratory diseases (2009), Expert Opin. Ther. Targets, 13, 287-295.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.65 pharmacology MMP-12 plays a predominant role in the inflammatory process induced by cigarette smoke, and therefore is potentially an important therapeutic target for the treatment of chronic obstructive pulmonary diseases Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.65 additional information development of pulmonary fibrosis in MMP-12 -/- knockout mice Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.65 TIMP-1 a major fibrogenic effector in lungs. Indeed, upon fibrogenic stimuli, large amounts of TIMP-1 in the remodeling tissue are believed to contribute to the creation of a non-degrading environment, leading to the alteration of protease-anti-protease balance, extracellular matrix accumulation, and tissue fibrosis. MMP-12 deficiency does not seem to be involved in TIMP-1 regulation Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.65 22000
-
 x * 54000, pro-MMP-12, x * 22000, active mature MMP-12 Homo sapiens
3.4.24.65 54000
-
 x * 54000, pro-MMP-12, x * 22000, active mature MMP-12 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.65 Elastin + H2O Mus musculus
-
 ?
-
 ?
3.4.24.65 Elastin + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.65 Homo sapiens
-
-
-
3.4.24.65 Mus musculus
-
 Balb/c and C57BL/6 mice
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.65 proteolytic modification pro-MMP-12 is activated to mature MMP-12 Mus musculus
3.4.24.65 proteolytic modification pro-MMP-12 is activated to mature MMP-12 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.65 epithelial cell bronchial Homo sapiens
-
3.4.24.65 lung
-
 Mus musculus
-
3.4.24.65 lung
-
 Homo sapiens
-
3.4.24.65 macrophage alveolar Homo sapiens
-
3.4.24.65 smooth muscle cell airway Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.65 alpha1-antitrypsin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.65 alpha1-antitrypsin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.65 Elastin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.65 Elastin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.65 Fibronectin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.65 Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.65 Gelatin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.65 Gelatin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.65 Laminin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.65 Laminin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.65 additional information MMP-12 has in vitro, a wide variety of potential substrates, including type IV collagen, fibronectin, laminin, and gelatin, as well as non-matrix proteins such as alpha1-antitrypsin and latent TNF-alpha Mus musculus ?
-
 ?
3.4.24.65 additional information MMP-12 has in vitro, a wide variety of potential substrates, including type IV collagen, fibronectin, laminin, and gelatin, as well as non-matrix proteins such as alpha1-antitrypsin and latent TNF-alpha Homo sapiens ?
-
 ?
3.4.24.65 TNF-alpha + H2O
-
 Mus musculus ?
-
 ?
3.4.24.65 TNF-alpha + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.65 Type IV collagen + H2O
-
 Mus musculus ?
-
 ?
3.4.24.65 Type IV collagen + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.65 ? x * 54000, pro-MMP-12, x * 22000, active mature MMP-12 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.24.65 macrophage metalloelastase
-
 Mus musculus
3.4.24.65 macrophage metalloelastase
-
 Homo sapiens
3.4.24.65 MMP-12
-
 Mus musculus
3.4.24.65 MMP-12
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.24.65 Mus musculus MMP-12 expression is upregulated by other matrix components such as hyaluronan fragments, cytokines, and growth factors, for example by TGF-beta, IFN-gamma and EGF, and serine proteases such as thrombin and plasmin up
3.4.24.65 Homo sapiens MMP-12 expression is upregulated by other matrix components such as hyaluronan fragments, cytokines, and growth factors, for example by TGF-beta, IFN-gamma and EGF, and serine proteases such as thrombin and plasmin up

General Information

EC Number General Information Comment Organism
3.4.24.65 physiological function macrophage elastase is able to degrade extracellular matrix components such as elastin and is involved in tissue remodeling in inflammatory respiratory diseases such as chronic obstructive pulmonary diseases, including emphysema. MMP-12 is also involved in asthma and fibrosis. Inhibitors demonstrate a reduction in both the inflammatory process and airspace enlargement in lung tissue. MMP-12 plays a predominant role in the inflammatory process induced by cigarette smoke Homo sapiens
3.4.24.65 physiological function macrophage elastase is able to degrade extracellular matrix components such as elastin and is involved in tissue remodeling in inflammatory respiratory diseases such as chronic obstructive pulmonary diseases, including emphysema. MMP-12 is involved in fibrosis, mechanism, overview. Balb/c mice are resistant to the development of pulmonary fibrosis, while C57BL/6 mice are not, overview Mus musculus