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Literature summary extracted from

  • Swords, R.; Mahalingam, D.; ODwyer, M.; Santocanale, C.; Kelly, K.; Carew, J.; Giles, F.
    Cdc7 kinase - a new target for drug development (2010), Eur. J. Cancer, 46, 33-40.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.1 (5Z)-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylidene)-2-thioxoimidazolidin-4-one
-
 Homo sapiens
2.7.11.1 (S)-2-(2-aminopyrimidiny-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridinione
-
 Homo sapiens
2.7.11.1 2-(2-aminopyrimidin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
-
 Homo sapiens
2.7.11.1 2-phenyl-5-(pyridin-4-yl)-1H-pyrrole-3-carboxamide
-
 Homo sapiens
2.7.11.1 6-(3-chlorophenyl)-4-(1H-indazol-5-yl)pyrimidin-2(1H)-one
-
 Homo sapiens
2.7.11.1 7,9-dimethyl-8-(prop-2-en-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amine
-
 Homo sapiens
2.7.11.1 BMS-863233
-
 Homo sapiens
2.7.11.1 N-ethyl-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-3a,6a-dihydro-1H-thieno[3,2-c]pyrazole-5-carboxamide
-
 Homo sapiens
2.7.11.1 N-[2-(4-fluorophenyl)ethyl]-5-[2-[(methylsulfonyl)amino]pyrimidin-4-yl]thiophene-2-carboxamide
-
 Homo sapiens
2.7.11.1 P53
-
 Homo sapiens
2.7.11.1 PHA-767491 nanomolar, ATP-competitive, Cdc7 inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + Cdk2 interacting protein Homo sapiens
-
 ADP + phosphorylated Cdk2 interacting protein
-
 ?
2.7.11.1 ATP + cell division cycle 7 Homo sapiens
-
 ADP + phosphorylated cell division cycle 7
-
 ?
2.7.11.1 ATP + claspin Homo sapiens
-
 ADP + phosphorylated claspin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.1 breast
-
 Homo sapiens
-
2.7.11.1 colon
-
 Homo sapiens
-
2.7.11.1 lung
-
 Homo sapiens
-
2.7.11.1 additional information both proteins show increased expression in 50% of the examined tumor cell lines of the NCI-60 panel and an additional panel of 5 leukemia cell lines. Expression is also confirmed in primary patient samples of breast, colon and lung Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + Cdk2 interacting protein
-
 Homo sapiens ADP + phosphorylated Cdk2 interacting protein
-
 ?
2.7.11.1 ATP + cell division cycle 7
-
 Homo sapiens ADP + phosphorylated cell division cycle 7
-
 ?
2.7.11.1 ATP + claspin
-
 Homo sapiens ADP + phosphorylated claspin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 Cdc7 kinase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.1 0.000002
-
-
 Homo sapiens (S)-2-(2-aminopyrimidiny-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridinione
2.7.11.1 0.000003
-
-
 Homo sapiens 2-phenyl-5-(pyridin-4-yl)-1H-pyrrole-3-carboxamide
2.7.11.1 0.000005
-
-
 Homo sapiens 6-(3-chlorophenyl)-4-(1H-indazol-5-yl)pyrimidin-2(1H)-one
2.7.11.1 0.000007
-
-
 Homo sapiens 2-(2-aminopyrimidin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
2.7.11.1 0.00001
-
-
 Homo sapiens PHA-767491
2.7.11.1 0.001
-
 IC50 less than 0.001 mM Homo sapiens N-ethyl-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-3a,6a-dihydro-1H-thieno[3,2-c]pyrazole-5-carboxamide