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Literature summary extracted from
- Conversion of the anti-tumor agent tasidotin (ILX651) to its active metabolite by prolyl oligopeptidase (2010), Enzyme Microb. Technol., 46, 246-251.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.26 | tasidotin | - |
Elizabethkingia meningoseptica |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.26 | 0.238 | - |
tasidotin | - |
Elizabethkingia meningoseptica | |
| 3.4.21.26 | 0.25 | - |
Z-Gly-Pro-4-nitroanilide | - |
Elizabethkingia meningoseptica | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | Elizabethkingia meningoseptica | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.26 | - |
Elizabethkingia meningoseptica |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | tasidotin + H2O | assay at pH 6.8, 37°C | Elizabethkingia meningoseptica | tert-butylamine + ? | - |
? | |
| 3.4.21.26 | Z-Gly-Pro-4-nitroanilide + H2O | chromogenic assay, assay at pH 7.0, 37°C, reaction stopped by addition of sodium acetate | Elizabethkingia meningoseptica | Z-Gly-Pro + p-nitroaniline | - |
? | |
| 3.4.21.26 | Z-Gly-Pro-7-amido-4-methylcoumarin | fluorogenic assay, assay at pH 6.8, 37°C, reaction stopped by addition of acetic acid | Elizabethkingia meningoseptica | Z-Gly-Pro + 7-amino-4-methylcoumarin | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | prolyl oligopeptidase | - |
Elizabethkingia meningoseptica |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.26 | 37 | - |
assay at | Elizabethkingia meningoseptica |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.26 | 0.311 | - |
tasidotin | chromogenic assay | Elizabethkingia meningoseptica | |
| 3.4.21.26 | 0.42 | - |
tasidotin | fluorogenic assay | Elizabethkingia meningoseptica | |
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Release 2023.1 (January 2023)
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