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Literature summary extracted from
- Study of acetylcholinesterase inhibitors using CE with contactless conductivity detection (2009), Electrophoresis, 30, 3442-3448.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.7 | galanthamine | a naturally occurring alkaloid and a drug for the treatment of mild to moderate Alzheimer's disease | Electrophorus electricus |  |
| 3.1.1.7 | huperzine A | a reversible AChE inhibitor | Electrophorus electricus | |
| 3.1.1.7 | additional information | inhibitor analysis using capillary electrophoresis with contactless conductivity detection, method development, overview | Electrophorus electricus | |
| 3.1.1.7 | paraoxon | an organophosphate compound, a quasi-irreversible AChE inhibitor | Electrophorus electricus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.7 | acetylcholine + H2O | Electrophorus electricus | - |
acetate + choline | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | Electrophorus electricus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | commercial preparation | - |
Electrophorus electricus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.7 | acetylcholine + H2O | - |
Electrophorus electricus | acetate + choline | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.7 | AChE | - |
Electrophorus electricus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 37 | - |
assay at | Electrophorus electricus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 7 | 9 | - |
Electrophorus electricus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.7 | 0.0014 | - |
pH 8.0, 37°C | Electrophorus electricus | huperzine A | |
| 3.1.1.7 | 0.0018 | - |
pH 8.0, 37°C | Electrophorus electricus | galanthamine | |
| 3.1.1.7 | 0.004 | - |
pH 8.0, 37°C | Electrophorus electricus | paraoxon | |
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Release 2023.1 (January 2023)
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