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Literature summary extracted from

  • Sounni, N.E.; Dehne, K.; van Kempen, L.; Egeblad, M.; Affara, N.I.; Cuevas, I.; Wiesen, J.; Junankar, S.; Korets, L.; Lee, J.; Shen, J.; Morrison, C.J.; Overall, C.M.; Krane, S.M.; Werb, Z.; Boudreau, N.; Coussens, L.M.
    Stromal regulation of vessel stability by MMP14 and TGFbeta (2010), Dis. Model. Mech., 3, 317-332.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.80 additional information generation of mutant Cola1(I)r/r mice, phenotype, overview. The mouse model of age-related dermal fibrosis, where MMP14 activity and TGFbeta bioavailability are chronically elevated, or in mice that ectopically express TGFbeta in the epidermis, cutaneous vessels are resistant to acute vessel leakage. Inhibition of ALK5 further enhances vascular leakage into the interstitium and facilitated increases delivery of high molecular weight compounds into premalignant tissue and tumors. Steady-state leakage of capillaries in back skin is also higher in MMP14 null mice versus age-matched heterozygous and wild-type littermates, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.80 GM6001 a broad-spectrum metalloproteinase inhibitor Homo sapiens
3.4.24.80 GM6001 a broad-spectrum metalloproteinase inhibitor Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.80 Homo sapiens
-
-
-
3.4.24.80 Mus musculus
-
 wild-type C57BL/6 and mutant Cola1(I)r/r mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.80 blood vessel
-
 Homo sapiens
-
3.4.24.80 blood vessel e.g. capillaries in back skin Mus musculus
-
3.4.24.80 skin
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
3.4.24.80 matrix metalloproteinase 14
-
 Mus musculus
3.4.24.80 matrix metalloproteinase 14
-
 Homo sapiens
3.4.24.80 MMP14
-
 Mus musculus
3.4.24.80 MMP14
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.24.80 malfunction loss of MMP14 activity increases steady-state vascular leakage, MMP14 activity impacts vascular leakage, mechanism, overview Mus musculus
3.4.24.80 malfunction loss of MMP14 activity increases steady-state vascular leakage, MMP14 activity impacts vascular leakage, mechanism, overview Homo sapiens
3.4.24.80 metabolism type I collagen fibrils posttranslationally regulate perivascular MMP activity and TGFbeta bioavailability, which in turn regulate vascular homeostasis by altering vessel stability and leakage. Matrix metalloproteinase 14 and transforming growth factor beta 1 are involved in a pathway regulating vessel stability in tissues, the pathway mediates vessel stability and vascular response to tissue injury Mus musculus
3.4.24.80 metabolism type I collagen fibrils posttranslationally regulate perivascular MMP activity and TGFbeta bioavailability, which in turn regulate vascular homeostasis by altering vessel stability and leakage. Matrix metalloproteinase 14 and transforming growth factor beta 1 are involved in a pathway regulating vessel stability in tissues, the pathway mediates vessel stability and vascular response to tissue injury Homo sapiens
3.4.24.80 physiological function MMP14 regulates TGFbeta bioactivity and vascular stability, MMP14 also regulates the bioavailability of several chemokines and growth factors. MMP14-mediated resistance to vascular and VEGF leakage is accompanied by decreased appearance of leakage sites in vessels with perivascular cell coverage Mus musculus