EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.1.23 | expressed in HeLa cells | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.23 | 6-methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one | URB754, inhibition of brain MAGL expressed in HeLa cells, no inhibition of membrane-bound MAGL. Is not selective for MAGL | Rattus norvegicus | |
3.1.1.23 | alpha-methyl-1-arachidonoyl glycerol | compound O-1428, inhibits both cytosolic and membrane-bound MAGL | Rattus norvegicus | |
3.1.1.23 | chlorpyrifos oxon | is not selective for MAGL | Rattus norvegicus | |
3.1.1.23 | ethyl octylphosphonofluoridate | is not selective for MAGL | Rattus norvegicus | |
3.1.1.23 | isopropyl dodecylfluorophosphonate | is not selective for MAGL | Rattus norvegicus | |
3.1.1.23 | methyl octylphosphonofluoridate | is not selective for MAGL | Rattus norvegicus | |
3.1.1.23 | additional information | is not inhibited by 1 mM N-arachidonylsuccinimide | Rattus norvegicus | |
3.1.1.23 | N-arachidonylmaleimide | inhibits membrane-bound MAGL selectively | Rattus norvegicus | |
3.1.1.23 | S-nonylbenzodioxaphosphorin oxide | is not selective for MAGL | Rattus norvegicus | |
3.1.1.23 | [1,1'-biphenyl]-3-yl-carbamic acid, cyclohexyl ester | URB602, noncompetetive selective inhibitor | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.1.23 | cytosol | - |
Rattus norvegicus | 5829 | - |
3.1.1.23 | membrane | - |
Rattus norvegicus | 16020 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.23 | Homo sapiens | - |
- |
- |
3.1.1.23 | Mus musculus | - |
- |
- |
3.1.1.23 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.23 | brain | - |
Rattus norvegicus | - |
3.1.1.23 | cerebellum | - |
Rattus norvegicus | - |
3.1.1.23 | additional information | Bv-2 cells do not express MAGL mRNA | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.23 | 2-arachidonoylglycerol + H2O | - |
Rattus norvegicus | arachidonic acid + glycerol | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.23 | MAGL | - |
Mus musculus |
3.1.1.23 | MAGL | - |
Homo sapiens |
3.1.1.23 | MAGL | - |
Rattus norvegicus |
3.1.1.23 | monoacylglycerol lipase | - |
Mus musculus |
3.1.1.23 | monoacylglycerol lipase | - |
Homo sapiens |
3.1.1.23 | monoacylglycerol lipase | - |
Rattus norvegicus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.1.1.23 | 0.00000031 | - |
cytosolic MAGL | Rattus norvegicus | S-nonylbenzodioxaphosphorin oxide | |
3.1.1.23 | 0.00000076 | - |
cytosolic MAGL | Rattus norvegicus | isopropyl dodecylfluorophosphonate | |
3.1.1.23 | 0.000003 | - |
cytosolic MAGL | Rattus norvegicus | ethyl octylphosphonofluoridate | |
3.1.1.23 | 0.000003 | - |
cytosolic MAGL | Rattus norvegicus | methyl octylphosphonofluoridate | |
3.1.1.23 | 0.000034 | - |
cytosolic MAGL | Rattus norvegicus | chlorpyrifos oxon | |
3.1.1.23 | 0.00014 | - |
membrane-bound MAGL | Rattus norvegicus | N-arachidonylmaleimide | |
3.1.1.23 | 0.0002 | - |
MAGL expressed in HeLa cells | Rattus norvegicus | 6-methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one | |
3.1.1.23 | 0.01 | - |
cytosolic MAGL | Rattus norvegicus | alpha-methyl-1-arachidonoyl glycerol | |
3.1.1.23 | 0.015 | - |
cytosolic MAGL | Rattus norvegicus | alpha-methyl-1-arachidonoyl glycerol | |
3.1.1.23 | 0.028 | - |
cytosolic MAGL | Rattus norvegicus | [1,1'-biphenyl]-3-yl-carbamic acid, cyclohexyl ester | |
3.1.1.23 | 0.071 | - |
membrane-bound MAGL | Rattus norvegicus | alpha-methyl-1-arachidonoyl glycerol | |
3.1.1.23 | 0.075 | - |
MAGL expressed in HeLa cells | Rattus norvegicus | [1,1'-biphenyl]-3-yl-carbamic acid, cyclohexyl ester |