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Literature summary extracted from
- Angiotensin converting enzyme inhibitor induced angio-oedema: a review of the pathophysiology and risk factors (2010), Clin. Exp. Allergy, 40, 50-61.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | angiotensin converting enzyme inhibitor | ACE-I, inhibition is impacting both the renin-angiotensin cascade and the degradation metabolism of bradykinin, inhibition mechanism, overview. ACE-I is used as therapeutic agent in congestive heart failure, diabetic nephropathy, hypertension, and coronary artery disease. ACE-I medications can induce chronic cough, hypotension, hyperkalemia, bone marrow depression, angioedema, and rarely, hepatic failure. Angioedema involves a subcutaneous swelling reaction that evolves over several hours and is not associated with itching or pain, pathomechanism, detailed overview | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | angiotensin I + H2O | Homo sapiens | - |
angiotensin II + His-Leu | - |
? |  |
| 3.4.15.1 | bradykinin + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | heart | - |
Homo sapiens | - |
| 3.4.15.1 | kidney | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | angiotensin I + H2O | - |
Homo sapiens | angiotensin II + His-Leu | - |
? | |
| 3.4.15.1 | bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | ACE | - |
Homo sapiens |
| 3.4.15.1 | angiotensin converting enzyme | - |
Homo sapiens |
| 3.4.15.1 | kininase II | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | metabolism | ACE is involved in the renin-angiotensin-aldosterone system, overview | Homo sapiens |
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Release 2023.1 (January 2023)
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