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Literature summary extracted from

  • Chalbot, S.; Zetterberg, H.; Blennow, K.; Fladby, T.; Grundke-Iqbal, I.; Iqbal, K.
    Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease (2009), Clin. Chem., 55, 2171-2179.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.1.4 medicine potential of PLA2 as a biomarker in screening neuroinflammatory disorders in both clinical and research settings Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.4
-
Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 1-palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine competitive inhibitor toward sPLA2, dose-dependent inhibition Homo sapiens
3.1.1.4 1-palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine competitive inhibitor toward recombinant sPLA2, dose-dependent inhibition Mus musculus
3.1.1.4 additional information is not inhibited by bromoenol lactone or AACOCF3 (arachidonyl trifluoromethyl ketone) Homo sapiens
3.1.1.4 additional information recombinant sPLA2 is not inhibited by bromoenol lactone or AACOCF3 (arachidonyl trifluoromethyl ketone) Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.4 Ca2+ is required for catalytic activity. With increase in the concentration of calcium, increase of recombinant PLA2 activity Homo sapiens
3.1.1.4 Ca2+ is required for catalytic activity. With increase in the concentration of calcium, increase of recombinant sPLA2 activity Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Homo sapiens
-
-
-
3.1.1.4 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 cerebrospinal fluid
-
Homo sapiens
-
3.1.1.4 serum sPLA2 activity relative to protein concentration is 2.5fold higher in serum than in lumbar cerebrospinal fluid Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 1,2-bis-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoyl)-sn-glycero-3-phosphocholine + H2O
-
Mus musculus ?
-
?
3.1.1.4 1,2-bis-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoyl)-sn-glycero-3-phosphocholine + H2O
-
Homo sapiens ?
-
?
3.1.1.4 1,2-dioleoyl-L-alpha-phosphatidylcholine + H2O
-
Mus musculus ?
-
?
3.1.1.4 1,2-dioleoyl-L-alpha-phosphatidylcholine + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 secretory Ca2+-dependent PLA2
-
Mus musculus
3.1.1.4 secretory Ca2+-dependent PLA2
-
Homo sapiens
3.1.1.4 sPLA2
-
Mus musculus
3.1.1.4 sPLA2
-
Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.1.4 physiological function sPLA2 activity is present in lumbar cerebrospinal fluid from healthy individuals 20-77 years old that does not depend on either sex or age. Cerebrospinal fluid sPLA2 activity is increased in patients with Alzheimer disease Homo sapiens