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Literature summary extracted from

  • Peruzzi, D.; Mori, F.; Conforti, A.; Lazzaro, D.; De Rinaldis, E.; Ciliberto, G.; La Monica, N.; Aurisicchio, L.
    MMP11: a novel target antigen for cancer immunotherapy (2009), Clin. Cancer Res., 15, 4104-4113.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.B3 medicine MMP11 is a novel broadly expressed tumor associated antigen and a target candidate for cancer immunotherapy. Possible use of murine MMP11 as tumor-associated antigen for vaccination of human cancer patients. MMP11 vaccine induces cell-mediated and antibody immune response and exerts significant antitumoral protection in mice with colon cancer in prophylactic and therapeutic settings Mus musculus
3.4.24.B3 medicine MMP11 is a novel broadly expressed tumor associated antigen and a target candidate for cancer immunotherapy. Possible use of murine MMP11 as tumor-associated antigen for vaccination of human cancer patients. MMP11 vaccine induces cell-mediated and antibody immune response and exerts significant antitumoral protection in mice with colon cancer in prophylactic and therapeutic settings Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B3 from NIH-3T3 cells, establishing of a chemically induced, MMP11-overexpressing colon cancer model, overview Mus musculus
3.4.24.B3 MMP11, expression analysis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B3 additional information HLA-A2.1 transgenic mice are used to identify reactive epitopes as tools to assess immunogenicity in humans, identification of human MHC class I epitopes within human MMP11 Homo sapiens
3.4.24.B3 additional information HLA-A2.1 transgenic mice are used to identify reactive epitopes as tools to assess immunogenicity in humans, MMP11 vaccine in 1,2-dimethylhydrazine-colon cancer model, overview Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B3 Zn2+ dependent on Mus musculus
3.4.24.B3 Zn2+ dependent on Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B3 Homo sapiens
-
-
-
3.4.24.B3 Mus musculus
-
 Balb/c mice
-
3.4.24.B3 Mus musculus BALB/c
-
 Balb/c mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B3 breast
-
 Homo sapiens
-
3.4.24.B3 breast cancer cell
-
 Homo sapiens
-
3.4.24.B3 carcinoma cell
-
 Mus musculus
-
3.4.24.B3 colon
-
 Homo sapiens
-
3.4.24.B3 colonic cancer cell
-
 Homo sapiens
-
3.4.24.B3 gastric cancer cell
-
 Homo sapiens
-
3.4.24.B3 intestine
-
 Mus musculus
-
3.4.24.B3 kidney
-
 Homo sapiens
-
3.4.24.B3 lung
-
 Homo sapiens
-
3.4.24.B3 lung cancer cell
-
 Homo sapiens
-
3.4.24.B3 additional information MMP11 is overexpressed in carcinomas compared to healthy tissue Homo sapiens
-
3.4.24.B3 NIH-3T3 cell
-
 Mus musculus
-
3.4.24.B3 renal cancer cell
-
 Homo sapiens
-
3.4.24.B3 stomach
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B3 MMP11
-
 Mus musculus
3.4.24.B3 MMP11
-
 Homo sapiens
3.4.24.B3 stromelysin 3
-
 Mus musculus
3.4.24.B3 stromelysin 3
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.24.B3 malfunction role of MMP11 in cancer progression, MMP11 expression correlates with aggressive profile and invasiveness of different types of carcinoma Mus musculus
3.4.24.B3 malfunction role of MMP11 in cancer progression, MMP11 expression correlates with aggressive profile and invasiveness of different types of carcinoma Homo sapiens