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Literature summary extracted from

  • Liu, J.; Huan, C.; Chakraborty, M.; Zhang, H.; Lu, D.; Kuo, M.S.; Cao, G.; Jiang, X.C.
    Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice (2009), Circ. Res., 105, 295-303.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.8.27 medicine SMS2 is a potential therapeutic target for treatment of atherosclerosis Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.27 ceramide + phosphatidylcholine Mus musculus
-
 sphingomyelin + 1,2-diacyl-sn-glycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.27 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.27 macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.27 ceramide + phosphatidylcholine
-
 Mus musculus sphingomyelin + 1,2-diacyl-sn-glycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.27 SMS2
-
 Mus musculus
2.7.8.27 sphingomyelin synthase 2
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.8.27 malfunction SMS2 deficiency causes significant induction of cholesterol efflux in vitro and in vivo, SMS2 deficiency in the macrophages reduces atherosclerosis in mice Mus musculus