Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Takashima, S.
    Phosphorylation of myosin regulatory light chain by myosin light chain kinase, and muscle contraction (2009), Circ. J., 73, 208-213.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+ MLCK is maximally activated by about 0.001 mM of Ca2+ Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 brain smMLCK expresses in almost every tissue, including brain Rattus norvegicus
-
2.7.11.18 cardiac muscle cMLCK is exclusively expressed in cardic muscle, smMLCK expresses in almost every tissue, including cardiac muscles Rattus norvegicus
-
2.7.11.18 colon smMLCK expresses in almost every tissue, including colon Rattus norvegicus
-
2.7.11.18 kidney smMLCK expresses in almost every tissue, including kidney Rattus norvegicus
-
2.7.11.18 liver smMLCK expresses in almost every tissue, including liver Rattus norvegicus
-
2.7.11.18 lung smMLCK expresses in almost every tissue, including lung Rattus norvegicus
-
2.7.11.18 additional information MLCK's are not expressed in leukocytes Rattus norvegicus
-
2.7.11.18 placenta smMLCK expresses in almost every tissue, including plaeta Rattus norvegicus
-
2.7.11.18 skeletal muscle skeletal muscle expresses a specific MLCK called skeletal-muscle-type myosin light chain kinase, smooth muscle myosin light chain kinase expresses in almost every tissue including skeletal muscles Rattus norvegicus
-
2.7.11.18 small intestine smMLCK expresses in almost every tissue, incnluding small intestine Rattus norvegicus
-
2.7.11.18 smooth muscle smMLCK expresses in almost every tissue, including smooth muscles Rattus norvegicus
-
2.7.11.18 spleen smMLCK expresses in almost every tissue, including spleen Rattus norvegicus
-
2.7.11.18 thymus smMLCK expresses in almost every tissue, including thymus Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain
-
 Rattus norvegicus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin regulatory light chain
-
 Rattus norvegicus ADP + myosin regulatory light chain phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 cMLKCk cardiac myosin light chain kinase Rattus norvegicus
2.7.11.18 MLCK
-
 Rattus norvegicus
2.7.11.18 myosin light chain kinase
-
 Rattus norvegicus
2.7.11.18 skMLCK skeletal muscle myosin light chain kinase Rattus norvegicus
2.7.11.18 smMLCK smooth muscle myosin light chain kinase Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
 Rattus norvegicus
2.7.11.18 Calmodulin dependent on Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.7.11.18 physiological function MLCK phosphorylates myosin regulatory light chain and controls muscle contraction of skeletal muscle, smooth muscle, and cardiac muscle Rattus norvegicus