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Literature summary extracted from

  • Manos-Turvey, A.; Bulloch, E.M.M.; Rutledge, P.J.; Baker, E.N.; Lott, J.S.; Payne, R.J.
    Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI) (2010), ChemMedChem, 5, 1067-1079.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.2.99.21 docking studies of inhibitors (E)-3-(1-carboxyprop-1-enyloxy)-2-hydroxybenzoic acid, 3-(1-carboxy-3-methylbut-1-enyloxy)-2-hydroxybenzoic acid, 3-(1-carboxybut-1-enyloxy)-2-hydroxybenzoic acid, and 3-(1-carboxy-2-phenylvinyloxy)-2-hydroxybenzoic acid Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.99.21 (E)-3-(1-carboxyprop-1-enyloxy)-2-hydroxybenzoic acid low micromolar inhibition of both isochorismate lyase and anthranilate synthase Mycobacterium tuberculosis
4.2.99.21 3-(1-carboxy-2-phenylvinyloxy)-2-hydroxybenzoic acid low micromolar inhibition of both isochorismate lyase and anthranilate synthase Mycobacterium tuberculosis
4.2.99.21 3-(1-carboxy-3-methylbut-1-enyloxy)-2-hydroxybenzoic acid low micromolar inhibition of both isochorismate lyase and anthranilate synthase Mycobacterium tuberculosis
4.2.99.21 3-(1-carboxybut-1-enyloxy)-2-hydroxybenzoic acid low micromolar inhibition of both isochorismate lyase and anthranilate synthase Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.99.21 0.0021
-
 isochorismate pH 8.0, 25°C Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
4.2.99.21 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.99.21 isochorismate
-
 Mycobacterium tuberculosis salicylate + pyruvate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.99.21 salicylate synthase
-
 Mycobacterium tuberculosis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.99.21 0.8
-
 isochorismate pH 8.0, 25°C Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.99.21 0.012
-
 3-(1-carboxybut-1-enyloxy)-2-hydroxybenzoic acid pH 8.0, 25°C Mycobacterium tuberculosis
4.2.99.21 0.013
-
 (E)-3-(1-carboxyprop-1-enyloxy)-2-hydroxybenzoic acid pH 8.0, 25°C Mycobacterium tuberculosis
4.2.99.21 0.014
-
 3-(1-carboxy-3-methylbut-1-enyloxy)-2-hydroxybenzoic acid pH 8.0, 25°C Mycobacterium tuberculosis
4.2.99.21 0.021
-
 3-(1-carboxy-2-phenylvinyloxy)-2-hydroxybenzoic acid pH 8.0, 25°C Mycobacterium tuberculosis