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Literature summary extracted from

  • Aurbek, N.; Herkert, N.M.; Koller, M.; Thiermann, H.; Worek, F.
    Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: Is there a structure-activity relationship? (2010), Chem. Biol. Interact., 187, 215-219.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 ethyl N,N-di-isopropylphosphorofluoridate
-
 Homo sapiens
3.1.1.7 ethyl N,N-di-n-propylphosphoamidocyanidate
-
 Homo sapiens
3.1.1.7 ethyl N,N-diethylphosphorofluoridate
-
 Homo sapiens
3.1.1.7 ethyl N-ethylphosphorofluoridate
-
 Homo sapiens
3.1.1.7 ethyl N-methylphosphorofluoridate
-
 Homo sapiens
3.1.1.7 ethyl N-n-propylphosphorofluoridate
-
 Homo sapiens
3.1.1.7 ethylsarin
-
 Homo sapiens
3.1.1.7 iso-pentylsarin
-
 Homo sapiens
3.1.1.7 methylsarin
-
 Homo sapiens
3.1.1.7 additional information inhibitory potencies of sarin and tabun derivatives, overview Homo sapiens
3.1.1.7 n-butylsarin
-
 Homo sapiens
3.1.1.7 n-pentylsarin
-
 Homo sapiens
3.1.1.7 n-propylsarin
-
 Homo sapiens
3.1.1.7 neo-pentylsarin
-
 Homo sapiens
3.1.1.7 sarin
-
 Homo sapiens
3.1.1.7 sec-pentylsarin
-
 Homo sapiens
3.1.1.7 Tabun
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.7 acetylcholine + H2O Homo sapiens
-
 acetate + choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylcholine + H2O
-
 Homo sapiens acetate + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.7 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 7.4
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.7 additional information
-
 additional information inhibition kinetics Homo sapiens