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Literature summary extracted from

  • Pyne, S.; Lee, S.C.; Long, J.; Pyne, N.J.
    Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease (2009), Cell. Signal., 21, 14-21.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.4 additional information is N-ethylmaleimide insensitive Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.4 LPP1, LPP2 and LPP3 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.4 R127K/H223L negligible LPP1 activity, although each mutant is still able to form oligomers Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.4 membrane LPPs are integral membrane proteins with six transmembrane domains Homo sapiens 16020
-
3.1.3.4 additional information LPP1 and LPP3 are present in caveolae, localised to distinct lipid rafts Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.4 additional information is Mg2+ independent Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Drosophila melanogaster
-
-
-
3.1.3.4 Homo sapiens
-
-
-
3.1.3.4 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 central nervous system
-
 Drosophila melanogaster
-
3.1.3.4 embryonic fibroblast
-
 Mus musculus
-
3.1.3.4 posterior midgut
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 ceramide 1-phosphate + H2O
-
 Homo sapiens ceramide + phosphate
-
 ?
3.1.3.4 lysophosphatidic acid + H2O
-
 Homo sapiens monoacylglycerol + phosphate
-
 ?
3.1.3.4 additional information the catalytic site is arranged into three distinct domains: one substrate recognition site and two catalytic sites Homo sapiens ?
-
 ?
3.1.3.4 phosphatidic acid + H2O
-
 Homo sapiens 1,2-diacyl-sn-glycerol + phosphate
-
 ?
3.1.3.4 sphingosine 1-phosphate + H2O
-
 Homo sapiens sphingosine + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.4 dimer catalytic activity is required for dimerisation Drosophila melanogaster
3.1.3.4 hexamer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 lipid phosphate phosphatase
-
 Drosophila melanogaster
3.1.3.4 lipid phosphate phosphatase
-
 Mus musculus
3.1.3.4 lipid phosphate phosphatase
-
 Homo sapiens
3.1.3.4 LPP1
-
 Mus musculus
3.1.3.4 LPP1
-
 Homo sapiens
3.1.3.4 LPP2
-
 Homo sapiens
3.1.3.4 LPP3
-
 Homo sapiens
3.1.3.4 Wunen
-
 Drosophila melanogaster
3.1.3.4 wunen-2
-
 Drosophila melanogaster

Expression

EC Number Organism Comment Expression
3.1.3.4 Homo sapiens epidermal growth factor increases LPP3 mRNA in HeLa cells. Androgen increases LPP1 mRNA in adenocarcinoma cells up

General Information

EC Number General Information Comment Organism
3.1.3.4 physiological function physiologically relevant increases in LPP1 activity in mouse embryonic fibroblasts (isolated from transgenic mice with 20 gene copies of LPP1) reduces lysophosphatidic acid- and platelet-derived growth factor-activation of ERK-1/2 and migration, resulting from down-regulation of typical proteinkinase C isoform(s) which are required for regulation of cell migration Mus musculus
3.1.3.4 physiological function stable overexpression of LPP1 or LPP2 reduces sphingosine 1-phosphate, lysophosphatidic acid- and thrombin-induced activation of ERK-1/2 Homo sapiens
3.1.3.4 physiological function wunen generates a phospholipid gradient and thereby repels germ cells towards higher phospholipid levels and away from the midline. Wunen/wunen-2 also governs the death of mis-migrating germ cells and survival of pole cells which compete for a common phospholipid substrate with somatic cells Drosophila melanogaster