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Literature summary extracted from

  • Scanga, C.A.; Flynn, J.L.
    Mycobacterial infections and the inflammatory seesaw (2010), Cell Host Microbe, 7, 177-179.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.3.2.6 additional information positive correlation between LTA4H polymorphism and the amount of LTB4 produced in vitro by granulocytes from the affected individuals. Heterozygosity at LTA4H is also associated with increased LTB4 production in vivo resulting in enhanced protection from TB or leprosy Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Homo sapiens
-
 leukotriene B4 i.e. LTB4, a powerful proinflammatory agent ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 monocyte
-
 Homo sapiens
-
3.3.2.6 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?
3.3.2.6 leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4 i.e. LTB4, a powerful proinflammatory agent ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 LTA4 hydrolase
-
 Homo sapiens
3.3.2.6 LTA4H
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.3.2.6 physiological function leukotrienes are involved in antiinflammation via eicosanoids, lipid mediators derived from arachidonic acid including the proinflammatory leukotrienes as well as the anti-inflammatory lipoxins, complex interplay between proinflammatory leukotrienes and antiinflammatory lipoxins. The enzyme is important in the balance between proinflammatory and anti-inflammatory responses in tuberculosis Homo sapiens