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Literature summary extracted from

  • Williams, H.; Johnson, J.L.; Jackson, C.L.; White, S.J.; George, S.J.
    MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis (2010), Cardiovasc. Res., 87, 137-146.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.23 Fas ligand treatment with Fas ligand, Fas-L, increases levels of active MMP-7 by 80% Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.23 additional information MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview Mus musculus
3.4.24.23 additional information MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.23 batimastat i.e. BB-94, BB-94 significantly reduces the amount of N-cadherin fragment produced in response to Fas-L Homo sapiens
3.4.24.23 batimastat
-
 Mus musculus
3.4.24.23 additional information MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview Homo sapiens
3.4.24.23 additional information MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.23 N-cadherin + H2O Mus musculus recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% ?
-
 ?
3.4.24.23 N-cadherin + H2O Homo sapiens recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% ?
-
 ?
3.4.24.23 N-cadherin + H2O Mus musculus C57/BL6J recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.23 Homo sapiens
-
-
-
3.4.24.23 Mus musculus
-
 C57BL/6J mice
-
3.4.24.23 Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.23 additional information MMP-7 activity is significantly higher in atherosclerotic plaques than internal mammary arteries Homo sapiens
-
3.4.24.23 vascular smooth muscle cell
-
 Mus musculus
-
3.4.24.23 vascular smooth muscle cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.23 additional information MMP-7 assay using DQ-gelatin fluorescent substrate Mus musculus ?
-
 ?
3.4.24.23 additional information MMP-7 assay using DQ-gelatin fluorescent substrate Homo sapiens ?
-
 ?
3.4.24.23 additional information MMP-7 assay using DQ-gelatin fluorescent substrate Mus musculus C57/BL6J ?
-
 ?
3.4.24.23 N-cadherin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.23 N-cadherin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.23 N-cadherin + H2O recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% Mus musculus ?
-
 ?
3.4.24.23 N-cadherin + H2O recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% Homo sapiens ?
-
 ?
3.4.24.23 N-cadherin + H2O
-
 Mus musculus C57/BL6J ?
-
 ?
3.4.24.23 N-cadherin + H2O recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% Mus musculus C57/BL6J ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.23 matrix metalloprotease-7
-
 Mus musculus
3.4.24.23 matrix metalloprotease-7
-
 Homo sapiens
3.4.24.23 MMP-7
-
 Mus musculus
3.4.24.23 MMP-7
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.23 37
-
 assay at Mus musculus
3.4.24.23 37
-
 assay at Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.24.23 0.00001
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens batimastat

General Information

EC Number General Information Comment Organism
3.4.24.23 physiological function MMP-7 mediates cleavage of N-cadherin and promotes vascular smooth muscle cell apoptosis, that can lead to thinning of the fibrous cap and atherosclerotic plaque instability Homo sapiens
3.4.24.23 physiological function MMP-7 mediates cleavage of N-cadherin and promotes vascular smooth muscle cell apoptosis, that can lead to thinning of the fibrous cap and plaque instability Mus musculus