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Literature summary extracted from

  • Park, M.H.; Ahn, B.H.; Hong, Y.K.; Min, D.S.
    Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappaB/Sp1-mediated signaling pathways (2009), Carcinogenesis, 30, 356-365.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 phorbol 12-myristate 13-acetate a protein kinase C activator also activates PLD, activation is inhibited by 1-butanol Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.4 K758R catalytically inactive mutant of isozyme PLD2 Homo sapiens
3.1.4.4 K898R catalytically inactive mutant of isozyme PLD1 Homo sapiens
3.1.4.4 additional information overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappaB/Sp1-mediated signaling pathways Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 1-butanol
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 additional information Homo sapiens NF-kappaB and transcription factor Sp1 are essential transcriptional factors linking PLD to MMP-2 upregulation ?
-
 ?
3.1.4.4 phosphatidylcholine + H2O Homo sapiens
-
 choline + phosphatidic acid phosphatidic acid induces upregulation of MMP-2 mediated by protein kinase C, protein kinase A, nuclear factor-kappaB, and Sp1. Phosphatidic acid induces nuclear localization and the transactivation of NF-kappaB in glioma cells. ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
-
 isozymes PLD1 and PLD2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 A-172 cell a glioma cell line Homo sapiens
-
3.1.4.4 astrocyte
-
 Homo sapiens
-
3.1.4.4 glioma cell
-
 Homo sapiens
-
3.1.4.4 additional information phospholipase D isozymes are overexpressed in various human tumor tissues and involved in tumorigenesis Homo sapiens
-
3.1.4.4 T-98G cell a glioma cell line Homo sapiens
-
3.1.4.4 U-373MG cell a glioma cell line Homo sapiens
-
3.1.4.4 U-87MG cell a glioma cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 additional information NF-kappaB and transcription factor Sp1 are essential transcriptional factors linking PLD to MMP-2 upregulation Homo sapiens ?
-
 ?
3.1.4.4 phosphatidylcholine + H2O
-
 Homo sapiens choline + phosphatidic acid
-
 ?
3.1.4.4 phosphatidylcholine + H2O
-
 Homo sapiens choline + phosphatidic acid phosphatidic acid induces upregulation of MMP-2 mediated by protein kinase C, protein kinase A, nuclear factor-kappaB, and Sp1. Phosphatidic acid induces nuclear localization and the transactivation of NF-kappaB in glioma cells. ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.4.4 malfunction phospholipase D isozymes are overexpressed in various human tumor tissues and involved in tumorigenesis. The increased expression of PLD and its enzymatic activity in the glioma stimulate the secretion and expression of matrix metalloproteinase 2, MMP-2 and induce the invasiveness of glioma cells, mechanism, overview Homo sapiens